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Titolo:
SYNAPTIC COEXISTENCE OF AMPA AND NMDA RECEPTORS IN THE RAT HIPPOCAMPUS - A POSTEMBEDDING IMMUNOGOLD STUDY
Autore:
HE Y; JANSSEN WGM; MORRISON JH;
Indirizzi:
MT SINAI SCH MED,NEUROBIOL AGING LABS,DEPT GERIATR & ADULT DEV,BOX 1639,1 GUSTAVE L LEVY PL NEW YORK NY 10029 MT SINAI SCH MED,NEUROBIOL AGING LABS,DEPT GERIATR & ADULT DEV NEW YORK NY 10029 CUNY MT SINAI SCH MED,FISHBERG RES CTR NEUROBIOL NEW YORK NY 10029
Titolo Testata:
Journal of neuroscience research
fascicolo: 4, volume: 54, anno: 1998,
pagine: 444 - 449
SICI:
0360-4012(1998)54:4<444:SCOAAN>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLUTAMATE RECEPTORS; CEREBRAL-CORTEX; CA2+-PERMEABLE AMPA; CA2+ PERMEABILITY; SILENT SYNAPSES; NERVOUS-SYSTEM; NEURONS; CHANNELS; SUBUNIT; COLOCALIZATION;
Keywords:
GABA; EXCITATORY AMINO ACIDS; GLUR2; NMDAR1; ELECTRON MICROSCOPY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
Y. He et al., "SYNAPTIC COEXISTENCE OF AMPA AND NMDA RECEPTORS IN THE RAT HIPPOCAMPUS - A POSTEMBEDDING IMMUNOGOLD STUDY", Journal of neuroscience research, 54(4), 1998, pp. 444-449

Abstract

Synaptic distributions oft N-methyl-D-aspartate (NMDA) and alpha-amino-3-hydroxy-5-methylisoxazolepropionic acid (AMPA) receptor subunits, NMDAR1 and GluR2, respectively, were examined by electron microscopy with the high spatial resolution of postembedding immunogold localization. We provide direct evidence for colocalization at individual axodendritic asymmetric synapses within the CA1 subfield of rat hippocampus. AMPA/NMDA receptor colocalization was found broth in gamma-aminobutyric acid (GABA)ergic dendrites and non-GABAergic dendritic shafts, as well as dendritic spines, Some asymmetric synapses were found to contain only NMDAR1 or GluR2; however, most immunopositive synapses contained both subunits. Many NMDAR1 and/or GluR2 immunopositive profiles received GABAergic innervation at an adjacent synapse, providing a, substrate for GABAergic modulation of both GluR classes, These data suggest that excitatory neuronal transmission in CA1 neurons may generally involve activation of both NMDA and AMPA receptor subunits at a single synapse, however they also offer ultrastructural evidence for NMDAR1-only synapses that might represent silent synapses, J. Neurosci. Res. 54:444-449, 1998, (C) 1998 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 15:12:01