Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
NO EVIDENCE FOR INVOLVEMENT OF THE LEPTIN GENE IN ANOREXIA-NERVOSA, BULIMIA-NERVOSA, UNDERWEIGHT OR EARLY-ONSET EXTREME OBESITY - IDENTIFICATION OF 2 NOVEL MUTATIONS IN THE CODING SEQUENCE AND A NOVEL POLYMORPHISM IN THE LEPTIN GENE LINKED UPSTREAM REGION
Autore:
HINNEY A; BORNSCHEUER A; DEPENBUSCH M; MIERKE B; TOLLE A; MIDDEKE K; ZIEGLER A; ROTH H; GERBER G; ZAMZOW K; BALLAUFF A; HAMANN A; MAYER H; SIEGFRIED W; LEHMKUHL G; POUSTKA F; SCHMIDT MH; HERMANN H; HERPERTZDAHLMANN BM; FICHTER M; REMSCHMIDT H; HEBEBRAND J;
Indirizzi:
UNIV MARBURG,DEPT CHILD & ADOLESCENT PSYCHIAT,CLIN RES GRP MARBURG GERMANY UNIV MARBURG,INST MED BIOMETRY & EPIDEMIOL MARBURG GERMANY UNIV MARBURG,INST HUMAN GENET MARBURG GERMANY UNIV HAMBURG,HOSP EPPENDORF,DEPT MED D-20246 HAMBURG GERMANY CHILDRENS HOSP HOCHRIED MURNAU GERMANY OBES TREATMENT CTR INSULA BERCHTESGADEN GERMANY UNIV COLOGNE,DEPT CHILD & ADOLESCENT PSYCHIAT COLOGNE GERMANY UNIV FRANKFURT,DEPT CHILD & ADOLESCENT PSYCHIAT D-6000 FRANKFURT GERMANY UNIV HEIDELBERG,DEPT CHILD & ADOLESCENT PSYCHIAT HEIDELBERG GERMANY KLIN ROSENECK PRIEN AM CHIEMSEE GERMANY DEPT CHILD & ADOLESCENT PSYCHIAT AACHEN GERMANY
Titolo Testata:
Molecular psychiatry
fascicolo: 6, volume: 3, anno: 1998,
pagine: 539 - 543
SICI:
1359-4184(1998)3:6<539:NEFIOT>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN OB GENE; BODY-MASS INDEX; ALLELE DISTRIBUTIONS; MARKERS FLANKING; WEIGHT; ABSENCE; LINKAGE; ADOLESCENTS; DEFICIENCY; RECEPTOR;
Keywords:
CHILDHOOD AND ADOLESCENT OBESITY; TRANSMISSION DISEQUILIBRIUM; OBESE GENE; MUTATION ANALYSIS; EATING DISORDERS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
A. Hinney et al., "NO EVIDENCE FOR INVOLVEMENT OF THE LEPTIN GENE IN ANOREXIA-NERVOSA, BULIMIA-NERVOSA, UNDERWEIGHT OR EARLY-ONSET EXTREME OBESITY - IDENTIFICATION OF 2 NOVEL MUTATIONS IN THE CODING SEQUENCE AND A NOVEL POLYMORPHISM IN THE LEPTIN GENE LINKED UPSTREAM REGION", Molecular psychiatry, 3(6), 1998, pp. 539-543

Abstract

Mutations in the leptin gene can result in profound obesity in both rodents and humans.(1-3) In humans, serum leptin levels correlate with body mass index(4) (BMI: kg m(-2)). However, in patients with anorexianervosa (AN) leptin levels are lower than in BMI-matched healthy controls.(5) We had previously argued that genes involved in weight regulation should be considered as candidate genes for AN.(6) To investigatethis hypothesis we screened the coding region of the leptin gene and part of the leptin gene linked upstream region (LEGLUR) in 49 patientswith AN and 315 children and adolescents with extreme obesity. Two never mutations in the coding region (Ser-91-Ser; Glu-126-Gln), each found in a single proband, and a novel polymorphism in the LEGLUR (position -1387 G/A; frequency of both alleles approximately 0.50) were identified. Tests for association of LEGLUR polymorphism alleles were negative by comparing allele frequencies between 115 AN patients, 71 bulimia nervosa patients, 315 extremely obese children and adolescents, 141 healthy underweights and 50 controls that were not selected for body weight. Tests for transmission disequilibrium were also negative. Hence, an influence of variations in the leptin gene on eating disorders orextreme early onset obesity could not be detected.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/07/20 alle ore 17:40:39