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Titolo:
DIRECT DETERMINATION OF DOPAMINE D-4 RECEPTORS IN NORMAL AND SCHIZOPHRENIC POSTMORTEM BRAIN-TISSUE - A [H-3]NGD-94-1 STUDY
Autore:
LAHTI RA; ROBERTS RC; COCHRANE EV; PRIMUS RJ; GALLAGER DW; CONLEY RR; TAMMINGA CA;
Indirizzi:
UNIV MARYLAND,MARYLAND PSYCHIAT RES CTR,POB 21247 CATONSVILLE MD 21228 NEUROGEN CORP BRANFORD CT 06405
Titolo Testata:
Molecular psychiatry
fascicolo: 6, volume: 3, anno: 1998,
pagine: 528 - 533
SICI:
1359-4184(1998)3:6<528:DDODDR>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
MESSENGER-RNA EXPRESSION; ENTORHINAL CORTEX; D4 RECEPTORS; ABNORMALITIES; LOCALIZATION; STRIATUM; NUCLEUS; BINDING; RAT;
Keywords:
DOPAMINE; SCHIZOPHRENIA; D-4 RECEPTOR; POSTMORTEM; HUMAN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
R.A. Lahti et al., "DIRECT DETERMINATION OF DOPAMINE D-4 RECEPTORS IN NORMAL AND SCHIZOPHRENIC POSTMORTEM BRAIN-TISSUE - A [H-3]NGD-94-1 STUDY", Molecular psychiatry, 3(6), 1998, pp. 528-533

Abstract

Using an indirect subtraction binding technique and human postmortem tissue, several laboratories(1-3) reported finding increases in dopamine D-4 receptors in caudate nuclei of schizophrenic patients, althoughothers(4-6) have not replicated these findings. NGD-94-1 is a selective D-4 antagonist with low affinity for the D-2 and D-3 receptors.(7,8) [H-3]NGD-94-1 has been used in this study to directly determine the density of D-4 receptors in normals (n = 13) and schizophrenic subjects (n = 7) off antipsychotic drugs for at least 3 months prior to death, or on antipsychotic (n = 7) drugs at the time of death. Human postmortem coronal brain sections were incubated with [H-3]NGD-94-1 and autoradiograms developed; and binding in pertinent regions was quantified. In normals, the highest density of [H-3]NGD-94-1 binding was in the hippocampus (68 fmol mg(-1), temporal (33), insular (30), and entorhinal cortices (24.9). Significant increases in [H-3]NGD-94-1 density in schizophrenics (n = 14) vs normals (n = 13) were observed in the entorhinal cortex (46%) at both low and high magnifications. The increases observed in the schizophrenics were found in both schizophrenics off antipsychotic drugs for at least 3 months prior to death and those on antipsychotic drugs at the time of death. Thus, the changes may be disease-related and not a consequence of pharmacological treatment. No significant differences were found between the two schizophrenic groups inany brain area studied.

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Documento generato il 19/01/20 alle ore 06:48:52