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Titolo:
CONTROL OF CALCIUM IN SKELETAL-MUSCLE EXCITATION-CONTRACTION COUPLING- IMPLICATIONS FOR MALIGNANT HYPERTHERMIA
Autore:
WINGERTZAHN MA; OCHS RS;
Indirizzi:
ST JOHNS UNIV,DEPT PHARM & ALLIED HLTH JAMAICA NY 11439 ST JOHNS UNIV,DEPT PHARM & ALLIED HLTH JAMAICA NY 11439
Titolo Testata:
Molecular genetics and metabolism ( Molecular genetics and metabolism (Print))
fascicolo: 2, volume: 65, anno: 1998,
pagine: 113 - 120
SICI:
1096-7192(1998)65:2<113:COCISE>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
CYCLIC ADP-RIBOSE; CA2+ RELEASE CHANNEL; RYANODINE RECEPTOR; INOSITOL 1,4,5-TRISPHOSPHATE; SARCOPLASMIC-RETICULUM; INTRACELLULAR CA2+; DIHYDROPYRIDINE RECEPTOR; CA2+-RELEASE CHANNELS; CARDIAC-MUSCLE; SMOOTH-MUSCLE;
Keywords:
SKELETAL MUSCLE; CALCIUM; EXCITATION-CONTRACTION; MALIGNANT HYPERTHERMIA; RYANODINE RECEPTOR; INOSITOL TRISPHOSPHATE;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
69
Recensione:
Indirizzi per estratti:
Citazione:
M.A. Wingertzahn e R.S. Ochs, "CONTROL OF CALCIUM IN SKELETAL-MUSCLE EXCITATION-CONTRACTION COUPLING- IMPLICATIONS FOR MALIGNANT HYPERTHERMIA", Molecular genetics and metabolism ( Molecular genetics and metabolism (Print)), 65(2), 1998, pp. 113-120

Abstract

The missing link in our understanding of excitation-contraction coupling (ECC) in skeletal muscle is the mechanism by which Ca2+ increases in the cytosol to trigger contraction. We discuss here a general background of intracellular Ca2+ handling, some characteristics of the major proteins involved in Ca2+ flow during ECC, and mechanisms currently believed to explain the increase in Ca2+ upon stimulation of muscle cells. These mechanisms include the calcium-induced calcium release, thedirect coupled mechanism in which a plasma membrane and sarcoplasmic reticulum membrane protein interact, and mechanisms involving Ca2+ secretagogues that are known to elicit increases in calcium in other cells, inositol trisphosphate, and cyclic ADP ribose. We also consider possible roles for proteins associated with the principal calcium releasechannel of the sarcoplasmic reticulum, the ryanodine receptor. Finally, we discuss malignant hyperthermia, a disease associated directly with aberrant control of muscle cell calcium release. (C) 1998 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/07/20 alle ore 17:36:27