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Titolo:
REDUCTION OF ADHESION FORMATION BY INTRAPERITONEAL ADMINISTRATION OF VARIOUS ANTIINFLAMMATORY AGENTS
Autore:
RODGERS KE; GIRGIS W; STAMAND K; CAMPEAU JD; DIZEREGA GS;
Indirizzi:
UNIV SO CALIF,LIVINGSTON RES CTR,DEPT OBSTET & GYNECOL,1321 N MISSIONRD LOS ANGELES CA 90033
Titolo Testata:
Journal of investigative surgery
fascicolo: 5, volume: 11, anno: 1998,
pagine: 327 - 339
SICI:
0894-1939(1998)11:5<327:ROAFBI>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
NONSTEROIDAL ANTIINFLAMMATORY DRUGS; PLASMINOGEN-ACTIVATOR PRODUCTION; RETINOIC ACID; FIBRINOLYTIC-ACTIVITY; PROCOAGULANT ACTIVITY; PREVENTION BARRIERS; ENDOTHELIAL-CELLS; DIPYRIDAMOLE; INHIBITION; RAT;
Keywords:
ADHESIONS; ANTIINFLAMMATORY; DIPYRIDAMOLE; PERITONEAL; QUINACRINE; RETINOID;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
74
Recensione:
Indirizzi per estratti:
Citazione:
K.E. Rodgers et al., "REDUCTION OF ADHESION FORMATION BY INTRAPERITONEAL ADMINISTRATION OF VARIOUS ANTIINFLAMMATORY AGENTS", Journal of investigative surgery, 11(5), 1998, pp. 327-339

Abstract

Adhesion formation is a major source of postoperative morbidity and mortality. Therefore, the reduction of postoperative adhesion formationwould be of clinical benefit. Various modalities have been shown to reduce adhesion formation, including fibrinolytic enzymes, nonsteroidalanti-inflammatory drugs, and barriers that reduce the apposition of sites of potential adhesion formation. In this report, the ability of three compounds with different mechanisms of action, all-trans-retinoicacid, quinacrine, and dipyridamole, to reduce the formation of intraperitoneal adhesions was examined in two rabbit models. In the sidewallmodel, the medicaments were administered via an Alzet miniosmotic pump for the entire postoperative interval. With all three agents, there was a reduction in the area of the sidewall injury that was involved in adhesions to the cecum and the bowel at both doses tested. In the same model, quinacrine also reduced the area of the sidewall injury thatwas involved in adhesions to the cecum and the bowel. At the higher concentrations of quinacrine, there was a deposition and walling off ofthe quinacrine at the site of delivery. In the double uterine horn model (DUH), the medicaments were administered via an Alzet miniosmotic pump to the area of injury for either 1, 2, 3, or 7 days. Administration of all three compounds for as little as 24 h after surgery significantly reduced the extent of adhesion formation. However, there was a further reduction in the amount of adhesion when the retinoic acid or dipyridamole was administered for 72 h postoperatively. However, when the quinacrine was administered for longer times postoperatively, the amount of adhesion reduction observed was less. These studies demonstrate that postoperative administration of retinoic acid, quinacrine, or dipyridamole to the site of injury reduced the formation of postoperative adhesions in two animal models.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 15:18:33