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Titolo:
ROLES OF KAPPA-OPIOID RECEPTOR AGONISTS IN LEARNING AND MEMORY IMPAIRMENT IN ANIMAL-MODELS
Autore:
HIRAMATSU M; KAMEYAMA T;
Indirizzi:
MEIJO UNIV,FAC PHARMACEUT SCI,DEPT CHEM PHARMACOL,TENPAKU KU NAGOYA AICHI 4688503 JAPAN
Titolo Testata:
Methods and findings in experimental and clinical pharmacology
fascicolo: 7, volume: 20, anno: 1998,
pagine: 595 - 599
SICI:
0379-0355(1998)20:7<595:ROKRAI>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
SPONTANEOUS-ALTERNATION PERFORMANCE; INDUCED DELAYED AMNESIA; SCOPOLAMINE-INDUCED IMPAIRMENT; PASSIVE-AVOIDANCE TASK; ACETYLCHOLINE-RELEASE; DYNORPHIN A-(1-13); MAMMALIAN BRAIN; MICE; RATS; IMPROVES;
Keywords:
KAPPA-OPIOID RECEPTOR AGONISTS; LEARNING; MEMORY; DYNORPHIN A (1-13); U-50,488H; CHOLINERGIC NEURONAL SYSTEMS; HIPPOCAMPUS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
M. Hiramatsu e T. Kameyama, "ROLES OF KAPPA-OPIOID RECEPTOR AGONISTS IN LEARNING AND MEMORY IMPAIRMENT IN ANIMAL-MODELS", Methods and findings in experimental and clinical pharmacology, 20(7), 1998, pp. 595-599

Abstract

The role of kappa-opioid receptor agonists on learning and memory is controversial. In this review, the effects of dynorphin A (1-13) and U-50,488H on learning and memory impairments in mice and rats are summarized. Muscarinic cholinergic antagonists and a nicotinic cholinergic antagonist significantly impaired learning a,ld memory in various behavioral tests. Administration of dynorphin A (1-13) or U-50,488H reversed the impairment of learning and memory. U-50,488H completely blockedthe decrease in acetylcholine release induced by mecamylamine, while it only partially blocked the increase of acetylcholine induced by scopolamine. The antagonistic effect of U-50,488H was abolished by pretreatment with nor-binaltorphimine, a selective kappa-opioid receptor antagonist. Dynorphin A (1-13) and U-50,488H did not affect the impairment of learning and memory induced by the blockade of NMDA-receptors by dizocilpine ((+)-MK-801. These results suggest that kappa-opioid receptor antagonist reverses the impairment of learning and memory induced by the blockade of cholinergic transmission and abolishes the decreaseof acetylcholine release via the kappa-opioid receptor-mediated neuronal system. (C) 1998 Prous Science. AII rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 10:54:20