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Titolo:
RECENT PROGRESS IN DEFINING THE ROLE OF SCAVENGER RECEPTORS IN LIPID TRANSPORT, ATHEROSCLEROSIS AND HOST-DEFENSE
Autore:
GREAVES DR; GOUGH PJ; GORDON S;
Indirizzi:
UNIV OXFORD,SIR WILLIAM DUNN SCH PATHOL,S PARKS RD OXFORD OX1 3RE ENGLAND
Titolo Testata:
Current opinion in lipidology
fascicolo: 5, volume: 9, anno: 1998,
pagine: 425 - 432
SICI:
0957-9672(1998)9:5<425:RPIDTR>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOW-DENSITY-LIPOPROTEIN; NECROSIS-FACTOR-ALPHA; CYSTEINE-RICH DOMAIN; FACTOR-KAPPA-B; A TYPE I/II; SR-BI; APOPTOTIC THYMOCYTES; LIPOTEICHOIC ACID; MICE LACKING; MACROPHAGE;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
63
Recensione:
Indirizzi per estratti:
Citazione:
D.R. Greaves et al., "RECENT PROGRESS IN DEFINING THE ROLE OF SCAVENGER RECEPTORS IN LIPID TRANSPORT, ATHEROSCLEROSIS AND HOST-DEFENSE", Current opinion in lipidology, 9(5), 1998, pp. 425-432

Abstract

Scavenger receptors bind and internalize modified lipoproteins. Thereare several different classes of scavenger receptors in mammalian cells and their relative contribution to lipid transport in normal physiology and pathological conditions such as atherosclerosis has been the subject of intense investigation. Mice with a disruption in the macrophage scavenger receptor SR-A gene exhibit a reduced size of atherosclerotic lesions and also exhibit an enhanced susceptibility to pathogensand endotoxic shock. In addition to their role in lipid transport, scavenger receptors play important roles in host defence and in the regulation of acquired immunity. Recent progress in delineating the mechanisms by which oxidized LDL effects changes in gene expression will be reviewed. Curr Opin Lipidol 9:425-432. (C) 1998 Lippincott Williams & Wilkins

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/05/20 alle ore 04:46:39