Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
NONPEPTIDIC CORTICOTROPIN-RELEASING HORMONE-RECEPTOR TYPE-1 ANTAGONIST REVERSES RESTRAINT STRESS-INDUCED SHORTENING OF SODIUM PENTOBARBITAL-INDUCED SLEEPING TIME OF RATS - EVIDENCE THAT AN INCREASE IN AROUSAL INDUCED BY STRESS IS MEDIATED THROUGH CRH RECEPTOR-TYPE-1
Autore:
ARAI K; OHATA H; SHIBASAKI T;
Indirizzi:
NIPPON MED COLL,DEPT PHYSIOL,BUNKYO KU,1-1-5 SENDAGI TOKYO 113 JAPAN
Titolo Testata:
Neuroscience letters
fascicolo: 2, volume: 255, anno: 1998,
pagine: 103 - 106
SICI:
0304-3940(1998)255:2<103:NCHTA>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
BRAIN; INVOLVEMENT;
Keywords:
CORTICOTROPIN-RELEASING HORMONE; AROUSAL; SODIUM PENTOBARBITAL-INDUCED SLEEPING TIME; RESTRAINT; CRH RECEPTOR TYPE 1; NONPEPTIDIC CRH RECEPTOR ANTAGONIST;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
18
Recensione:
Indirizzi per estratti:
Citazione:
K. Arai et al., "NONPEPTIDIC CORTICOTROPIN-RELEASING HORMONE-RECEPTOR TYPE-1 ANTAGONIST REVERSES RESTRAINT STRESS-INDUCED SHORTENING OF SODIUM PENTOBARBITAL-INDUCED SLEEPING TIME OF RATS - EVIDENCE THAT AN INCREASE IN AROUSAL INDUCED BY STRESS IS MEDIATED THROUGH CRH RECEPTOR-TYPE-1", Neuroscience letters, 255(2), 1998, pp. 103-106

Abstract

Stress shortens sodium pentobarbital (PbNa)-induced sleeping time through corticotropin-releasing hormone (CRH) in rats. We investigated whether this effect of brain CRH is mediated by CRH receptor type 1 (CRHR1) using a non-peptidic CRHR1 antagonist in rats. A 60 min period of restraint significantly shortened PbNa-induced sleeping time. This shortening was completely reversed by peripheral administration of CRHR1 antagonist. These results suggest that the stress-induced increase in arousal is mediated by CRHR1. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 21:43:57