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Titolo:
PREVALENCE OF JC VIRUS VIREMIA IN HIV-INFECTED PATIENTS WITH OR WITHOUT NEUROLOGICAL DISORDERS - A PROSPECTIVE-STUDY
Autore:
DUBOIS V; MORET H; LAFON ME; JANVRESSE CB; DUSSAIX E; ICART J; KARATERKI A; RUFFAULT A; TAOUFIK Y; VIGNOLI C; INGRAND D;
Indirizzi:
HOP PELLEGRIN,DEPT VIROL F-33076 BORDEAUX FRANCE HOP PELLEGRIN,DEPT VIROL F-33076 BORDEAUX FRANCE R DEBRE HOSP,DEPT MICROBIOL F-51092 REIMS FRANCE HOP CHARLES NICOLLE,DEPT MICROBIOL F-76031 ROUEN FRANCE HOP PAUL BROUSSE,DEPT MICROBIOL F-94800 VILLEJUIF FRANCE DEPT MICROBIOL F-31054 TOULOUSE FRANCE PONCHAILLOU HOSP,DEPT MICROBIOL F-35033 RENNES FRANCE LA TIMONE HOSP,DEPT MICROBIOL F-13005 MARSEILLE FRANCE
Titolo Testata:
Journal of neurovirology
fascicolo: 5, volume: 4, anno: 1998,
pagine: 539 - 544
SICI:
1355-0284(1998)4:5<539:POJVVI>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY; POLYMERASE CHAIN-REACTION; PERIPHERAL-BLOOD LEUKOCYTES; BRAIN-TISSUE; POLYOMAVIRUS INFECTION; CEREBROSPINAL-FLUID; GENOMIC SEQUENCES; BONE-MARROW; BK-VIRUS; DNA;
Keywords:
JCV; LEUKOCYTES; PLASMA; PCR; PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
V. Dubois et al., "PREVALENCE OF JC VIRUS VIREMIA IN HIV-INFECTED PATIENTS WITH OR WITHOUT NEUROLOGICAL DISORDERS - A PROSPECTIVE-STUDY", Journal of neurovirology, 4(5), 1998, pp. 539-544

Abstract

Progressive Multifocal Leukoencephalopathy (PML) is a severe demyelinating disease, which is rapidly fatal and is due to JC virus (JCV) infection, which especially occurs in HIV-infected patients, To investigate JCV pathophysiology and to evaluate the predictive value of JCV detection in blood, we looked for JCV DNA in leukocytes and plasma of 96 patients without any neurological symptoms and 109 patients with neurological diseases, among whom 19 were suffering from PML. JCV genome was detected in about 18% of all patients, i.e. 15.6% of patients with central nervous system disorders except PML, 13.5% of patients without neurological symptoms and significantly more often in PML patients (47.6%). Both leukocytes and plasma were tested; in plasma, JCV DNA was found in 36.1% of positive patients and in cells in 80.5%. Surprisinglyin seven instances only the plasma contained JCV genome. One-year follow-up of these patients showed that the absence of JCV DNA in blood was associated with a very low probability of developing PML (negative predictive value = 0.99).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/10/20 alle ore 20:59:06