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Titolo:
PLASMA GLICENTIN CONCENTRATION IN PATIENTS WITH CROHNS-DISEASE
Autore:
SASAKI M; MYOJO S; TSUJIKAWA T; FUJIYAMA Y; BAMBA T; SATOH T; SASAKI K;
Indirizzi:
SHIGA UNIV MED SCI,DEPT INTERNAL MED 2 OTSU SHIGA 5202192 JAPAN NISSHIN FLOUR MILLING CO LTD,PHARMACEUT RES CTR OOI SAITAMA 3568511 JAPAN
Titolo Testata:
Journal of clinical biochemistry and nutrition
fascicolo: 3, volume: 24, anno: 1998,
pagine: 147 - 155
SICI:
0912-0009(1998)24:3<147:PGCIPW>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
SMALL-BOWEL RESECTION; PANCREATIC HYPERPLASIA; INTESTINAL ADAPTATION; ENTEROGLUCAGON; GLUCAGON; RAT; PROLIFERATION; PROGLUCAGON; SECRETION; MUCOSA;
Keywords:
GLICENTIN; ENTEROGLUCAGON; CROHNS DISEASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
M. Sasaki et al., "PLASMA GLICENTIN CONCENTRATION IN PATIENTS WITH CROHNS-DISEASE", Journal of clinical biochemistry and nutrition, 24(3), 1998, pp. 147-155

Abstract

Enteroglucagon has been reported to have trophic effects on the intestinal mucosa, and is associated with proliferation and repair after various injuries of the small intestine. Glicentin is an active enteroglucagon, and is present in the largest amount in the intestine. We established a method for quantifying human plasma levels of glicentin, andmeasured these levels in patients with Crohn's disease. Twenty-three patients with Crohn's disease (14 males and 9 females) and 8 healthy adults were enrolled in this study. A sandwich ELISA method was used toquantify immunoreactive glicentin in plasma sampled from subjects fasting in the early morning and after the oral administration of 75 g glucose (Trelan G(R)). The plasma glicentin levels in fasting subjects were significantly higher in patients with active-stage Crohn's disease, and were similar between the remission-stage Crohn's disease and normal controls. These levels after glucose administration were significantly higher in patients with active-stage Crohn's disease than in those with the disease in remission or in healthy controls. However, the pattern of the changes in the plasma glicentin levels after the glucoseadministration was similar among the three groups. These data suggestthat plasma glicentin levels might reflect the pathological conditions and activity in Crohn's disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 01:59:13