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Titolo:
ANTI-HIV ANTIVIRAL ACTIVITY OF STAVUDINE IN A THYMIDINE KINASE-DEFICIENT CELLULAR-LINE
Autore:
TURRIZIANI O; SIMEONI E; DIANZANI F; ANTONELLI G;
Indirizzi:
UNIV ROMA LA SAPIENZA,INST VIROL,VIALE PORTA TIBURTINA 28 I-00185 ROME ITALY UNIV PISA,DEPT BIOMED PISA ITALY
Titolo Testata:
Antiviral therapy
fascicolo: 3, volume: 3, anno: 1998,
pagine: 191 - 194
SICI:
1359-6535(1998)3:3<191:AAAOSI>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-IMMUNODEFICIENCY-VIRUS; BLOOD MONONUCLEAR-CELLS; COMBINATION THERAPY; IN-VITRO; 2',3'-DIDEHYDRO-2',3'-DIDEOXYTHYMIDINE; PHOSPHORYLATION; METABOLISM; D4T; 3'-AZIDO-2',3'-DIDEOXYTHYMIDINE; 3'-AZIDO-3'-DEOXYTHYMIDINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
O. Turriziani et al., "ANTI-HIV ANTIVIRAL ACTIVITY OF STAVUDINE IN A THYMIDINE KINASE-DEFICIENT CELLULAR-LINE", Antiviral therapy, 3(3), 1998, pp. 191-194

Abstract

Stavudine (d4T) is a potent inhibitor of human immunodeficiency virustype 1 (HIV-1) reverse transcriptase. It is known that stavudine is metabolized in cells to the mono-, di- and triphosphate nucleotides butthe enzymes responsible for its phosphorylation are as yet unidentified. in particular, there are conflicting results concerning the role of thymidine kinase 1 (TK1) in stavudine metabolism. To gain new insights into this phenomenon we analysed the antiviral activity of stavudine in a TK1-deficient, resistant cell line. The results indicate that TK1 is responsible for the phosphorylation of stavudine but it is not the only enzyme involved in its activation. The other enzyme(s) that might be involved in the metabolism of stavudine, however, are not able to phosphorylate stavudine with the same efficiency as TK1. Since it has been shown that prolonged treatment with zidovudine may induce an in vivo defect in TK1 activity. it is tempting to speculate that patients treated for a long time with zidovudine could be resistant to further treatment with stavudine.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 09:08:36