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Titolo:
DIRECT QUANTIFICATION OF NOREPINEPHRINE SPILLOVER AND HORMONE OUTPUT FROM THE PANCREAS OF THE CONSCIOUS DOG
Autore:
DUNNING BE; SCOTT MF; NEAL DW; CHERRINGTON AD;
Indirizzi:
SANDOZ INC,RES INST,DEPT METAB DIS,PRECLIN RES,59 ROUTE 10 E HANOVER NJ 07936 VANDERBILT UNIV,SCH MED,DEPT MOL PHYSIOL & BIOPHYS NASHVILLE TN 37232
Titolo Testata:
American journal of physiology: endocrinology and metabolism
fascicolo: 5, volume: 35, anno: 1997,
pagine: 746 - 755
SICI:
0193-1849(1997)35:5<746:DQONSA>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
VAGAL NERVE-STIMULATION; INSULIN-SECRETION; POLYPEPTIDE RELEASE; GLUCOSE-METABOLISM; NEURAL ACTIVATION; CANINE PANCREAS; GLUCAGON; HYPOGLYCEMIA; MECHANISM; SOMATOSTATIN;
Keywords:
AUTONOMIC NERVOUS SYSTEM; HYPOGLYCEMIA; PANCREATIC HORMONE SECRETION; PANCREATIC POLYPEPTIDE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
39
Recensione:
Indirizzi per estratti:
Citazione:
B.E. Dunning et al., "DIRECT QUANTIFICATION OF NOREPINEPHRINE SPILLOVER AND HORMONE OUTPUT FROM THE PANCREAS OF THE CONSCIOUS DOG", American journal of physiology: endocrinology and metabolism, 35(5), 1997, pp. 746-755

Abstract

To estimate pancreatic neural activity and to assess the potential role of the pancreatic nerves in the regulation of hormone secretion, the methodology necessary to quantify neurotransmitter spillover and hormone output in the conscious dog was developed. A femoral artery and the superior pancreaticoduodenal vein (SPDV) were chronically cannulated, and a flow probe was placed on the SPDV. Hormone output was calculated using the pancreatic arteriovenous concentration difference and the SPDV plasma flow. Basal glucose levels were 103 +/- 1 mg/dl; the pancreatic outputs of insulin, glucagon, and pancreatic polypeptide (PP, an index of parasympathetic neural activity) were 2,900 +/- 700 mu U/min, 1,900 +/- 400 pg/min, and 9.3 +/- 4.6 ng/min, respectively. Pancreatic norepinephrine (NE) spillover was calculated similarly; however, pancreatic extraction of epinephrine was used as an index of NE extraction. Basal NE spillover was 3,600 +/- 700 pg/min, greatly exceeding that reported using anesthetized, laparotomized dogs. Intravenous glucose infusion increased plasma glucose to 146 +/- 13 mg/dl, increased insulin output approximately twofold, and suppressed glucagon output by similar to 50%. Hyperglycemia markedly reduced PP output. Hyperglycemia failed to influence pancreatic NE spillover. Insulin-induced hypoglycemia (36 +/- 2 mg/dl) completely suppressed insulin output and stimulated glucagon output (> 10-fold). Hypoglycemia increased NE spillover and PP output to 19,900 +/- 4,600 pg/min and 117 +/- 22 ng/min, respectively. We conclude that pancreatic neurotransmitter spillover in the basal state is much higher than previously appreciated and that neuralsignaling to the pancreas is responsive to physiological and pathophysiological changes in the metabolic state.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 21:40:41