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Titolo:
CIRCULATING OXYNTOMODULIN-LIKE IMMUNOREACTIVITY IN HEALTHY-CHILDREN AND CHILDREN WITH CELIAC-DISEASE
Autore:
LEQUELLEC A; CLAPIE M; CALLAMAND P; LEHMANN M; KERVRAN A; BATAILLE D; RIEU D;
Indirizzi:
HOP ST ELOI,SERV MED INTERNE A,2 AVE BERTIN SANS F-34295 MONTPELLIER 5 FRANCE HOP ARNAUD VILLENEUVE,INSERM U 376 MONTPELLIER FRANCE CHU MONTPELLIER,HOP ARNAUD VILLENEUVE,SERV PEDIAT 2 MONTPELLIER FRANCE CHU NIMES,HOP GASTON DOUMERGUE,DEPT MED INFORMAT NIMES FRANCE
Titolo Testata:
Journal of pediatric gastroenterology and nutrition
fascicolo: 5, volume: 27, anno: 1998,
pagine: 513 - 518
SICI:
0277-2116(1998)27:5<513:COIIHA>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
GASTRIC-ACID SECRETION; GUT-HORMONE PROFILE; PLASMA ENTEROGLUCAGON; DIURNAL PROFILE; PEPTIDES; MALABSORPTION; GLICENTIN; BOWEL; CELLS; RAT;
Keywords:
CELIAC DISEASE; GASTROINTESTINAL HORMONES; OXYNTOMODULIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
41
Recensione:
Indirizzi per estratti:
Citazione:
A. Lequellec et al., "CIRCULATING OXYNTOMODULIN-LIKE IMMUNOREACTIVITY IN HEALTHY-CHILDREN AND CHILDREN WITH CELIAC-DISEASE", Journal of pediatric gastroenterology and nutrition, 27(5), 1998, pp. 513-518

Abstract

Background: The aim of the study was to evaluate the new hormonal entity oxyntomodulin-like immunoreactivity in malabsorption states, and to assess its potential in celiac disease management. Methods: We measured basal and postprandial oxyntomodulin-like immunoreactivity values in 35 children divided into 3 groups: group 1 was composed of 13 children with celiac disease, either under a gluten-free diet (8 patients) or normal diet (5 patients); group 2 was composed of 8 children hospitalized for gastroenteritis or chronic diarrhea, without biological evidence of malabsorption nor abnormal jejunal mucosa; group 3 was composed of 22 control subjects. Results: Fasting and meal-stimulated levelsin the control group were 71 +/- 10 and 130 +/- 26 pmol/l, respectively. Mean concentrations were elevated in patients with celiac disease (basal = 349 +/- 254 pmol/l, postprandial = 446 +/- 332 pmol/l) and inthe group 2 (basal = 139 +/- 58 pmol/l, postprandial = 218 +/- 85 pmol/l), but the difference with control subjects did not reach statistical significance. In children with celiac disease, basal and stimulatedvalues correlated with the degree of malabsorption as assessed by hemoglobin (p = 0.006 and p = 0.01, respectively) and serum folate concentrations (p = 0.03 and p = 0.02, respectively). Conclusions: Oxyntomodulin-like immunoreactivity is noticeably higher in healthy children than previously measured in healthy adult subjects. This hormonal parameter is not an adequate diagnostic tool in celiac disease. Nevertheless, in the context of celiac disease, its elevation reflects the degree of malabsorption and may provide a quantitative approach of the extentof mucosal damage.

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Documento generato il 28/11/20 alle ore 00:35:55