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Titolo:
THE COMPLEMENT-SYSTEM AND ADAPTIVE IMMUNITY
Autore:
FEARON DT;
Indirizzi:
UNIV CAMBRIDGE,SCH CLIN MED,WELLCOME TRUST IMMUNOL UNIT,HILLS RD CAMBRIDGE CB2 2SP ENGLAND
Titolo Testata:
Seminars in immunology
fascicolo: 5, volume: 10, anno: 1998,
pagine: 355 - 361
SICI:
1044-5323(1998)10:5<355:TCAAI>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELL ANTIGEN RECEPTOR; FOLLICULAR DENDRITIC CELLS; LYN-DEFICIENT MICE; FC-GAMMA-RIIB; SIGNAL-TRANSDUCTION MOLECULE; TYROSINE-PHOSPHATASE 1C; C3/C4 BINDING-PROTEINS; T-DEPENDENT ANTIGEN; HUMAN LYMPHOCYTES-B; PHOSPHATIDYLINOSITOL 3-KINASE;
Keywords:
B LYMPHOCYTE; CD19; CD21; CD22; COMPLEMENT;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
74
Recensione:
Indirizzi per estratti:
Citazione:
D.T. Fearon, "THE COMPLEMENT-SYSTEM AND ADAPTIVE IMMUNITY", Seminars in immunology, 10(5), 1998, pp. 355-361

Abstract

The complement system covalently attaches C3d to microbial antigens which binds to CR2 on B lymphocytes, leading to a markedly enhanced adaptive immune response to that antigen. The enhancement is mediated by the cross-linking of the CR2-CD19 complex to mIg which augments the activation of several intracellular signalling pathways. Two additional receptors of the B lymphocyte, Fc gamma RIIB and CD22, have opposing effects when cross-linked to mIg, the former suppressing signalling by recruiting the inositol phosphatase, SHIP, and the latter by activating the phosphotyrosine phosphatase, SHP-1. Two principles emerge from these studies: innate immunity guides the adaptive immune response, andactivation of the B lymphocyte is determined by co-receptors which evaluate the biological characteristics of antigen.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 22:58:40