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Titolo:
A GENOME-WIDE SCAN FOR HUMAN OBESITY GENES REVEALS A MAJOR SUSCEPTIBILITY LOCUS ON CHROMOSOME-10
Autore:
HAGER J; DINA C; FRANCKE S; DUBOIS S; HOUARI M; VATIN V; VAILLANT E; LORENTZ N; BASDEVANT A; CLEMENT K; GUYGRAND B; FROGUEL P;
Indirizzi:
INST BIOL,CNRS EP 10,1 RUE PROF CALMETTE F-59019 LILLE FRANCE INST BIOL,CNRS EP 10 F-59019 LILLE FRANCE HOP HOTEL DIEU,DEPT NUTR PARIS FRANCE UNIV BONN,INST KLIN BIOCHEM D-5300 BONN GERMANY
Titolo Testata:
Nature genetics
fascicolo: 3, volume: 20, anno: 1998,
pagine: 304 - 308
SICI:
1061-4036(1998)20:3<304:AGSFHO>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
LEPTIN RECEPTOR GENE; HUMAN OB GENE; QUANTITATIVE TRAIT; MARKERS FLANKING; EXTREME OBESITY; PIMA-INDIANS; LINKAGE; MUTATION; ABSENCE; WEIGHT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
27
Recensione:
Indirizzi per estratti:
Citazione:
J. Hager et al., "A GENOME-WIDE SCAN FOR HUMAN OBESITY GENES REVEALS A MAJOR SUSCEPTIBILITY LOCUS ON CHROMOSOME-10", Nature genetics, 20(3), 1998, pp. 304-308

Abstract

Obesity, a common multifactorial disorder, is a major risk factor fortype 2 diabetes, hypertension and coronary heart disease(1) (CHD). According to the definition of the World Health Organization (WHO), approximately 6-10% of the population in Westernized countries are considered obese(2). Epidemiological studies have shown that 30-70% of the variation in body weight may be attributable to genetic factors. To date, two genome-wide scans using different obesity-related quantitative traits have provided candidate regions for obesity(3,4). We have undertaken a genome-wide scan in affected sibpairs to identify chromosomal regions linked to obesity in a collection of French families. Model-free multipoint linkage analyses revealed evidence for linkage to a region on chromosome 10p (MLS=4.85). Two further loci on chromosomes 5cen-qand 2p showed suggestive evidence for linkage of serum leptin levels in a genome-wide context. The peak on chromosome 2 coincided with the region containing the gene (POMC) encoding pro-opiome-lanocortin, a locus previously linked to leptin levels and fat mass in a Mexican-American population(3) and shown to be mutated in obese humans(5). Our results suggest that there is a major gene on chromosome 10p implicated inthe development of human obesity, and the existence of two further loci influencing leptin levels.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 20:23:38