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Titolo:
MODULATION OF SYNAPTIC EFFICACY AND SYNAPTIC DEPRESSION BY GLIAL-CELLS AT THE FROG NEUROMUSCULAR-JUNCTION
Autore:
ROBITAILLE R;
Indirizzi:
UNIV MONTREAL,CTR RECH SCI NEUROL,DEPT PHYSIOL MONTREAL PQ H3C 3J7 CANADA
Titolo Testata:
Neuron (Cambridge, Mass.)
fascicolo: 4, volume: 21, anno: 1998,
pagine: 847 - 855
SICI:
0896-6273(1998)21:4<847:MOSEAS>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERISYNAPTIC SCHWANN-CELLS; ASTROCYTES IN-SITU; INTRACELLULAR CALCIUM; TRANSMITTER RELEASE; GROWTH-FACTOR; G-PROTEINS; CA2+; CHANNELS; RECEPTORS; MUSCLE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
49
Recensione:
Indirizzi per estratti:
Citazione:
R. Robitaille, "MODULATION OF SYNAPTIC EFFICACY AND SYNAPTIC DEPRESSION BY GLIAL-CELLS AT THE FROG NEUROMUSCULAR-JUNCTION", Neuron (Cambridge, Mass.), 21(4), 1998, pp. 847-855

Abstract

The ability of perisynaptic glial cells to modulate transmitter release and synaptic depression was studied at the frog neuromuscular junction (nmj). Injection of GTP gamma S in perisynaptic Schwann cells (PSCs), glial cells at this synapse, induced a reduction in the amplitude of nerve-evoked synaptic responses but had no effect on the frequency,the amplitude, or the duration of the miniature endplate currents (MEPCs). Also, paired pulse facilitation was not affected. The reduction in transmitter release was mediated by pertussis toxin-(PTX) sensitiveand insensitive G proteins. Blockade of G proteins in PSCs with GDP beta S reduced synaptic depression induced by high frequency trains of stimuli, whereas activation of G proteins occluded it. Hence, the activation by endogenous neurotransmitters of G proteins in PSCs induced aprofound depression in neurotransmitter release.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 16/07/20 alle ore 06:32:49