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Titolo:
INHIBITION OF ANXIETY IN RATS BY ANTISENSE TO CHOLECYSTOKININ PRECURSOR PROTEIN
Autore:
COHEN H; KAPLAN Z; KOTLER M;
Indirizzi:
BEN GURION UNIV NEGEV,FAC HLTH SCI,MINIST HLTH,BEER SHEVA MENTAL HLTHCTR BEER SHEVA ISRAEL
Titolo Testata:
Biological psychiatry
fascicolo: 9, volume: 44, anno: 1998,
pagine: 915 - 917
SICI:
0006-3223(1998)44:9<915:IOAIRB>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
IN-VIVO; OLIGODEOXYNUCLEOTIDES; OLIGONUCLEOTIDES; INVIVO;
Keywords:
CHOLECYSTOKININ; ANXIETY; ANTISENSE OLIGODEOXYNUCLEOTIDE; ANIMAL MODEL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
19
Recensione:
Indirizzi per estratti:
Citazione:
H. Cohen et al., "INHIBITION OF ANXIETY IN RATS BY ANTISENSE TO CHOLECYSTOKININ PRECURSOR PROTEIN", Biological psychiatry, 44(9), 1998, pp. 915-917

Abstract

Background: Cholecystokinin (CCK) and its analogs generates anxiety in humans and measurable anxiety-like behaviors in rats. CCK receptor blockers have had mixed results as a treatment approach for anxiety disorders. Since CCK is a peptide, we explored another strategy to reduceCCK levels in brain by antisense oligodeoxynucleotide inhibition of DNA transcription or messenger RNA (mRNA) translation for CCK precursorprotein. Methods: Antisense oligodeoxynucleotide complementary to thestart coding region of rat CCK-precursor was intracerebroventricularly (icv) infused into rats three times at 24-hour intervals, Control groups received infusions of either a scramble sequence oligodeoxynucleotide or vehicle. On the fourth day, rats were assessed in the elevatedplus maze paradigm. Results: Compared to vehicle and scramble sequence oligodeoxynucleotide central, icy CCK-antisense exogenous administration for 3 days significantly diminished anxiety behavior in rats. Conclusions: Antisense inhibition of CCK-mediated anxiety could have therapeutic potential in human anxiety disorders. (C) 1998 Society of Biological Psychiatry.

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Documento generato il 29/03/20 alle ore 11:17:25