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Titolo:
PROTEIN-KINASE-C IN PLATELETS OF DEPRESSED-PATIENTS
Autore:
PANDEY GN; DWIVEDI Y; KUMARI R; JANICAK PG;
Indirizzi:
UNIV ILLINOIS,INST PSYCHIAT,1601 W TAYLOR ST CHICAGO IL 60612 UNIV ILLINOIS,DEPT PSYCHIAT CHICAGO IL 60612
Titolo Testata:
Biological psychiatry
fascicolo: 9, volume: 44, anno: 1998,
pagine: 909 - 911
SICI:
0006-3223(1998)44:9<909:PIPOD>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT-BRAIN; DISORDER; BINDING;
Keywords:
HUMAN PLATELETS; PROTEIN KINASE C; DEPRESSION; [H-3]PHORBOL DIBUTYRATE BINDING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
14
Recensione:
Indirizzi per estratti:
Citazione:
G.N. Pandey et al., "PROTEIN-KINASE-C IN PLATELETS OF DEPRESSED-PATIENTS", Biological psychiatry, 44(9), 1998, pp. 909-911

Abstract

Background: We studied the role of protein kinase C (PKC), a major regulatory enzyme and an important component of the phosphoinositide signaling system, in depression. Methods: PKC was determined using [H-3]phorbol dibutyrate (PDBu) as the radioligand in the membranal and cytosolic fractions of platelets obtained from hospitalized drug-free depressed patients during a baseline period and from drug-free normal control subjects. Results: We observed that the [H-3]PDBu binding was significantly higher in the cytosolic fraction obtained from platelets of depressed patients compared to normal control subjects. Conclusions: Our studies indicate increased formation of PKC in platelets of depressed patients. The significance and mechanisms involved in increased PKC in the cytosolic fraction of platelets are unclear but they suggest that increased PKC may be associated with the pathophysiology of depressive illness. (C) 1998 Society of Biological Psychiatry.

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Documento generato il 25/11/20 alle ore 17:29:07