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Titolo:
CCK IN ANXIETY AND COGNITIVE-PROCESSES
Autore:
DAUGE V; LENA I;
Indirizzi:
UNIV PARIS 05,CNRS,UFR SCI PHARMACEUT & BIOL,URA D1500,INSERM,U266 F-75270 PARIS 06 FRANCE
Titolo Testata:
Neuroscience and biobehavioral reviews
fascicolo: 6, volume: 22, anno: 1998,
pagine: 815 - 825
SICI:
0149-7634(1998)22:6<815:CIAAC>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHOLECYSTOKININ-B RECEPTOR; POSTERIOR NUCLEUS-ACCUMBENS; PANIC DISORDER PATIENTS; 2-TRIAL MEMORY TASK; ELEVATED PLUS-MAZE; GUINEA-PIG BRAIN; ENDOGENOUS ENKEPHALINS; BINDING-SITES; RAT-BRAIN; PHARMACOLOGICAL CHARACTERIZATION;
Keywords:
CHOLECYSTOKININ; CCK-B RECEPTOR BINDING SITES; CCK-B1; CCK-B2; STRESS; ANXIETY AND PANIC; DOPAMINE; ATTENTION AND MEMORY; NUCLEUS ACCUMBENS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
145
Recensione:
Indirizzi per estratti:
Citazione:
V. Dauge e I. Lena, "CCK IN ANXIETY AND COGNITIVE-PROCESSES", Neuroscience and biobehavioral reviews, 22(6), 1998, pp. 815-825

Abstract

Extensive studies were carried out on the involvement of the CCKergicsystem in anxiety-, panic- and stress-related behaviour. The stimulation of CCK-A or CCK-B receptors is implicated in the physical and psychological responses of CCK to stress. Furthermore, several selective CCK-B agonists produce anxiogenic-like effects, while CCK-B antagonistsinduce anxiolytic-like responses in several models of anxiety. However, BC264 a highly selective CCK-B agonist, does not produce anxiogenic-like effects but increases attention and/or memory. These effects aredependent on the dopaminergic systems. Together with biochemical data, this led to the hypothesis of the existence of two CCK-B binding sites, CCK-B1 and CCK-B2, which could correspond to different activation states of a single molecular entity. Investigations into CCK-B I and CCK-B2 systems might be of critical interest, since only one site, CCK-B1, appears to be responsible for the effects on anxiety. Furthermore,the improvement of attention and/or memory processes by CCK, through CCK-B2 receptors, could offer a new perspective in the treatment of attention and/or memory disorders. (C) 1998 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/07/20 alle ore 20:48:21