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Titolo:
PLACENTAL PATHOLOGY IN ANTIPHOSPHOLIPID SYNDROME
Autore:
LEVY RA; AVVAD E; OLIVEIRA J; PORTO LC;
Indirizzi:
HOSP UNIV PEDRO ERNESTO,DISCIPLINA REUMATOL,BLVD 28 SETEMBRO 77,SALA 333,VILA ISABEL BR-20551100 RIO JANEIRO BRAZIL UNIV ESTADO RIO DE JANEIRO,FAC CIENCIAS MED,DISCIPLINA REUMATOL RIO JANEIRO BRAZIL UNIV ESTADO RIO DE JANEIRO,FAC CIENCIAS MED,DEPT ANAT PATOL RIO JANEIRO BRAZIL UNIV ESTADO RIO DE JANEIRO,FAC CIENCIAS MED,DEPT HISTOL & EMBRIOL RIOJANEIRO BRAZIL
Titolo Testata:
Lupus
, volume: 7, anno: 1998, supplemento:, 2
pagine: 81 - 85
SICI:
0961-2033(1998)7:<81:PPIAS>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
SYSTEMIC LUPUS-ERYTHEMATOSUS; DECIDUAL VASCULOPATHY; ANTIBODIES; IMMUNOFLUORESCENT; ANTICOAGULANT; PREECLAMPSIA; LOCALIZATION; PREGNANCY; VILLITIS; DEATH;
Keywords:
ANTIPHOSPHOLIPID SYNDROME; PLACENTA; PREECLAMPSIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
R.A. Levy et al., "PLACENTAL PATHOLOGY IN ANTIPHOSPHOLIPID SYNDROME", Lupus, 7, 1998, pp. 81-85

Abstract

One of the major targets of antiphospholipid antibodies (aPL) is the placenta, the evolution of which during pregnancy has been well documented. Histopathological findings are related to gestational age, and several physiologic and pathologic alterations that occur during its development. The major findings in placentae from aPL positive patients are thrombosis, acute atherosis, a decreased number of syncytio-vascular membranes, increased number of syncytial knots and obliterative arteriopathy. These findings are not specific to the antiphospholipid syndrome (APS) and sometimes do not correlate with the fetal outcome. Histopathological study of placentae may elucidate mechanisms of action of aPL in fetal loss and other obstetric complications. In addition. itmay assist in the investigation of the differential diagnosis betweenAPS and pregnancy-induced hypertension. Immunohistochemical studies of local placental proteins contribute to this differential diagnosis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 05:45:18