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Titolo:
INVOLVEMENT OF OX40-OX40L INTERACTIONS IN THE INTESTINAL MANIFESTATIONS OF THE MURINE ACUTE GRAFT-VERSUS-HOST DISEASE
Autore:
STUBER E; VONFREIER A; MARINESCU D; FOLSCH UR;
Indirizzi:
CHRISTIAN ALBRECHTS UNIV KIEL,MED KLIN 1,ABT ALLGEMEINE INNERE MED,SCHITTENHELMSTR 12 D-24105 KIEL GERMANY
Titolo Testata:
Gastroenterology (New York, N.Y. 1943)
fascicolo: 5, volume: 115, anno: 1998,
pagine: 1205 - 1215
SICI:
0016-5085(1998)115:5<1205:IOOIIT>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
OX40 LIGAND; T-CELLS; GUT; IDENTIFICATION; LYMPHOCYTES; ACTIVATION; TENASCIN; KINETICS; INJURY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
E. Stuber et al., "INVOLVEMENT OF OX40-OX40L INTERACTIONS IN THE INTESTINAL MANIFESTATIONS OF THE MURINE ACUTE GRAFT-VERSUS-HOST DISEASE", Gastroenterology (New York, N.Y. 1943), 115(5), 1998, pp. 1205-1215

Abstract

Background & Aims: The intestinal histology of murine semiallogeneic graft-versus-host (GVH) disease is characterized by lymphocytic infiltrates, crypt hyperplasia, and villous atrophy. Mechanisms of T cell-mediated changes of the mucosal architecture were investigated. Methods:The rate of cellular apoptosis and proliferation, changes in the composition of extracellular matrix (ECM), and the role of OX40-OX40L interactions in the pathogenesis of villous atrophy and crypt hyperplasia were examined. Results: The rate of apoptosis and the number of proliferating cells were significantly increased in GVH animals compared with control animals. In addition, expression of tenascin, an ECM component, was down-regulated in GVH animals. Inhibition of OX40-OX40L interactions in GVH animals by administration of an OX40-Ig fusion protein completely prevented the development of crypt hyperplasia and villous atrophy in GVH animals. Tenascin expression was up-regulated in OX40-lg-treated mice compared with GVH animals, suggesting an important function of this ECM component in mucosal repair. Conclusions: The OX40-OX40L interaction is crucial in the pathogenesis of GVH, a T cell-mediated intestinal disease. The data suggest that the ECM component tenascinis probably relevant for the regeneration and maintenance of intestinal tissue architecture.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 10:51:42