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Titolo:
LONG-TERM SUPPLEMENTATION WITH A HIGH CHOLESTEROL DIET DECREASES THE RELEASE OF ATP FROM THE CAUDAL ARTERY IN AGED RATS
Autore:
HASHIMOTO M; SHINOZUKA K; TANABE Y; SHAHDAT HM; GAMOH S; GAMOH S; KWON YM; TANAKA Y; KUNITOMO M; MASUMURA S;
Indirizzi:
SHIMANE MED UNIV,DEPT PHYSIOL IZUMO SHIMANE 6938501 JAPAN SHIMANE MED UNIV,DEPT PHYSIOL IZUMO SHIMANE 6938501 JAPAN MUKOGAWA WOMENS UNIV,FAC PHARMACEUT SCI,DEPT PHARMACOL NISHINOMIYA HYOGO 663 JAPAN
Titolo Testata:
Life sciences (1973)
fascicolo: 21, volume: 63, anno: 1998,
pagine: 1879 - 1885
SICI:
0024-3205(1998)63:21<1879:LSWAHC>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
FATTY-ACID COMPOSITION; VASCULAR ENDOTHELIAL-CELLS; ADENINE NUCLEOSIDES; NUCLEOTIDES; METHOXAMINE; INVOLVEMENT; FLOW;
Keywords:
ATP RELEASE; HIGH CHOLESTEROL DIET; FATTY ACIDS; BLOOD PRESSURE; AGING; RAT CAUDAL ARTERY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
M. Hashimoto et al., "LONG-TERM SUPPLEMENTATION WITH A HIGH CHOLESTEROL DIET DECREASES THE RELEASE OF ATP FROM THE CAUDAL ARTERY IN AGED RATS", Life sciences (1973), 63(21), 1998, pp. 1879-1885

Abstract

We examined the effects of high cholesterol (HC) diet on the spontaneous and noradrenaline-induced release of ATP, ADP, AMP and adenosine from caudal arteries and on the plasma levels of these adenyl purines in aged (100-week-old) Wistar rats. Administration of this diet for 12 weeks significantly reduced spontaneous and noradrenaline (1 mu mol/L)-evoked release of adenyl purines from the caudal arteries relative torats given the control diet The unsaturation index of fatty acids (UI), which gives the average number of double bonds, of both the plasma and the caudal artery was significantly less in the HC diet-fed rats than in those fed the control diet. The HC diet for 12 weeks produced aslight but significant increase in systolic and diastolic blood pressure with advancing age. Regression analysis revealed a significant inverse relationship between the total amount of purines released from the artery and diastolic blood pressure, and also a positive relationship between the total amount of purines released and the UI of the caudal artery. These results suggest that the high cholesterol diet decreased the release of adenyl purines from the caudal arteries of aged rats, leading to an increase in blood pressure.

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Documento generato il 28/11/20 alle ore 01:02:22