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Titolo:
CYTOSKELETAL ASSEMBLY AND ATP RELEASE REGULATE ASTROCYTIC CALCIUM SIGNALING
Autore:
COTRINA ML; LIN JHC; NEDERGAARD M;
Indirizzi:
NEW YORK MED COLL,DEPT CELL BIOL & ANAT VALHALLA NY 10595 NEW YORK MED COLL,DEPT CELL BIOL & ANAT VALHALLA NY 10595 NEW YORK MED COLL,DEPT PATHOL VALHALLA NY 10595 NEW YORK MED COLL,DEPT NEUROSURG VALHALLA NY 10595
Titolo Testata:
The Journal of neuroscience
fascicolo: 21, volume: 18, anno: 1998,
pagine: 8794 - 8804
SICI:
0270-6474(1998)18:21<8794:CAAARR>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
GAP JUNCTIONAL COMMUNICATION; LIGHT CHAIN KINASE; CULTURED ASTROCYTES; GLIOMA-CELLS; CORTICAL ASTROCYTES; HORIZONTAL CELLS; SMOOTH-MUSCLE; DYE TRANSFER; GLIAL-CELLS; ACTIN;
Keywords:
CYTOCHALASIN; ACTIN; MYOSIN; CALCIUM WAVES; GLIOMA CELLS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
74
Recensione:
Indirizzi per estratti:
Citazione:
M.L. Cotrina et al., "CYTOSKELETAL ASSEMBLY AND ATP RELEASE REGULATE ASTROCYTIC CALCIUM SIGNALING", The Journal of neuroscience, 18(21), 1998, pp. 8794-8804

Abstract

We have studied the role of actin fiber assembly on calcium signalingin astrocytes. We found that (1) after astrocytes have been placed inculture, it takes several hours for organization of the definitive actin cytoskeleton. Actin organization and the number of cells engaged in calcium signaling increased in parallel. (2) Disruption of the actincytoskeleton attenuated the calcium wave propagation; cytochalasin D treatment reduced the number of astrocytes engaged in calcium signaling. (3) Propagation of calcium waves depends on cytoskeletal function; inhibition of myosin light chain kinase suppressed wave activity (4) Astrocytic calcium signaling is mediated by release of ATP and purinergic receptor stimulation, because agents that interfere with this cascade attenuated or reduced calcium signaling. Because purinergic receptors are fully functional shortly after plating and not affected by cytochalasin D, these observations indicate that cytoskeleton organizationis a prerequisite for interastrocytic calcium signaling mediated by release of ATP.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 12:41:35