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Titolo:
DETECTION OF DNA-ADDUCTS IN THE HUMAN ENDOMETRIUM - A LACK OF EVIDENCE
Autore:
CARMICHAEL PL; SARDAR S; NEVEN F; VANHOOF I; UGWUMADU A; BOURNE T; TOMAS E; HELLBERG P; HEWER AJ; PHILLIPS DH;
Indirizzi:
UNIV LONDON IMPERIAL COLL SCI TECHNOL & MED,DIV BIOMED SCI LONDON ENGLAND KLIN ST JAN BRUSSELS BELGIUM ST GEORGE HOSP TOOTING SW17 ENGLAND OULU UNIV HOSP OULU 90220 FINLAND SAHLGRENS UNIV HOSP S-41345 GOTHENBURG SWEDEN CANC RES INST,HADDOW LABS SURREY ENGLAND
Titolo Testata:
European journal of cancer
, volume: 34, anno: 1998, supplemento:, 4
pagine: 66 - 67
SICI:
0959-8049(1998)34:<66:DODITH>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
TAMOXIFEN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
2
Recensione:
Indirizzi per estratti:
Citazione:
P.L. Carmichael et al., "DETECTION OF DNA-ADDUCTS IN THE HUMAN ENDOMETRIUM - A LACK OF EVIDENCE", European journal of cancer, 34, 1998, pp. 66-67

Abstract

A study exploring DNA adducts in human endometria, utilising TLC-P-32-postlabelling, found no evidence for adducts in tamoxifen-treated women, however a subsequent Study utilising HPLC-P-32-postlabelling suggested that very low revels could be detected. We have sought to confirmor dispute these findings by reproducing the HPLC methodology at two centres, analysing endometrial DNA from 20 patients treated with 20 mg/day tamoxifen for between 22 and 65 months. Liver DNA isolated from tamoxifen-treated rats was used as a positive control. We found no convincing evidence for tamoxifen-derived DNA adducts in human endometrium. HPLC elution profiles were indistinguishable from those obtained from untreated women and from women taking the analogue toremifene. (C) 1998 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 04:04:09