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Titolo:
INTRATHORACIC MULTICENTRIC CASTLEMAN-DISEASE - CT FINDINGS IN 12 PATIENTS
Autore:
JOHKOH T; MULLER NL; ICHIKADO K; NISHIMOTO N; YOSHIZAKI K; HONDA O; TOMIYAMA N; NAITOH H; NAKAMURA H; YAMAMOTO S;
Indirizzi:
VANCOUVER HOSP & HLTH SCI CTR,855 W 12TH AVE VANCOUVER BC V5Z 1M9 CANADA VANCOUVER HOSP & HLTH SCI CTR VANCOUVER BC V5Z 1M9 CANADA OSAKA UNIV,SCH MED,DEPT RADIOL OSAKA 553 JAPAN OSAKA UNIV,SCH MED,DEPT MED OSAKA 553 JAPAN UNIV BRITISH COLUMBIA VANCOUVER BC V5Z 1M9 CANADA KUMAMOTO UNIV,SCH MED,DEPT INTERNAL MED 1 KUMAMOTO 860 JAPAN NATL KINKI CENT HOSP CHEST DIS,DEPT PATHOL OSAKA JAPAN
Titolo Testata:
Radiology
fascicolo: 2, volume: 209, anno: 1998,
pagine: 477 - 481
SICI:
0033-8419(1998)209:2<477:IMC-CF>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
LYMPHOPROLIFERATIVE DISORDERS; INTERSTITIAL PNEUMONIA; PATHOLOGICAL FINDINGS; LUNG; AMYLOIDOSIS; FEATURES;
Keywords:
CASTLEMAN DISEASE; COMPUTED TOMOGRAPHY (CT), HELICAL; COMPUTED TOMOGRAPHY (CT), THIN-SECTION; HAMARTOMA; LYMPHATIC SYSTEM, HYPERPLASIA; PNEUMONITIS, LYMPHOCYTIC INTERSTITIAL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
T. Johkoh et al., "INTRATHORACIC MULTICENTRIC CASTLEMAN-DISEASE - CT FINDINGS IN 12 PATIENTS", Radiology, 209(2), 1998, pp. 477-481

Abstract

Purpose: To assess the computed tomographic (CT) findings of intrathoracic involvement in multicentric Castleman disease. Materials and methods: The study comprised 12 patients with lymph node biopsy-proved Castleman disease and multicentric involvement. The patients were aged 23-58 years (mean age, 42.9 years; five men, seven women). Seven patients underwent open lung biopsy (n = 3) or transbronchial lung biopsy (n= 4), which demonstrated lymphocytic interstitial pneumonitis. Results: All patients had systemic symptoms, polyclonal hypergammaglobulinemia, and bilateral hilar and mediastinal lymph node enlargement. The nodes a showed mild to moderate enhancement after intravenous administration of contrast material. At thin-section CT, all 12 patients showed poorly defined centrilobular nodules. Thin-walled cysts were present in 10 patients, thickening of the bronchovascular bundles in 10, and interlobular septal thickening in nine. Less common findings were subpleural nodules, ground-glass attenuation, air-space consolidation, and bronchiectasis. Conclusion: Multicentric Castleman disease is characterized by the presence of systemic symptoms, bilateral hilar and mediastinal lymphadenopathy, and centrilobular nodular opacities. The pulmonary parenchymal findings are due to the associated lymphocytic interstitial pneumonitis.

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Documento generato il 15/07/20 alle ore 13:53:06