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Titolo:
IDENTIFICATION OF NOCICEPTIN IN HUMAN CEREBROSPINAL-FLUID - COMPARISON OF LEVELS IN PAIN AND NONPAIN STATES
Autore:
BROOKS H; ELTON CD; SMART D; ROWBOTHAM DJ; MCKNIGHT AT; LAMBERT DG;
Indirizzi:
UNIV LEICESTER,LEICESTER ROYAL INFIRM,DEPT ANAESTHESIA & PAIN MANAGEMENT LEICESTER LE1 5WW LEICS ENGLAND UNIV LEICESTER,LEICESTER ROYAL INFIRM,DEPT ANAESTHESIA & PAIN MANAGEMENT LEICESTER LE1 5WW LEICS ENGLAND LEICESTER ROYAL INFIRM,NHS DIV ANAESTHESIA LEICESTER LE1 5WW LEICS ENGLAND UNIV CAMBRIDGE,PARKE DAVIS NEUROSCI RES CTR CAMBRIDGE CB2 2QB ENGLAND
Titolo Testata:
Pain
fascicolo: 1, volume: 78, anno: 1998,
pagine: 71 - 73
SICI:
0304-3959(1998)78:1<71:IONIHC>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
OPIOID RECEPTOR; ORPHANIN-FQ; RAT;
Keywords:
NOCICEPTIN; ORPHANIN FQ; ORPHAN OPIOID LIKE RECEPTOR; CEREBROSPINAL FLUID; LABOR; RADIOIMMUNOASSAY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
6
Recensione:
Indirizzi per estratti:
Citazione:
H. Brooks et al., "IDENTIFICATION OF NOCICEPTIN IN HUMAN CEREBROSPINAL-FLUID - COMPARISON OF LEVELS IN PAIN AND NONPAIN STATES", Pain, 78(1), 1998, pp. 71-73

Abstract

We have measured plasma and cerebrospinal fluid (CSF) concentrations of nociceptin, the endogenous agonist of the orphan opioid receptor like receptor (ORL-1). We studied two groups of ten patients presenting for elective Caesarean section (Group E) or in established labour and requiring combined spinal epidural anaesthesia for pain relief (Group L). Nociceptin was identified in all CSF samples with mean +/- SD concentrations of 52.49 +/- 34.25 and 63.39 +/- 33.26 pg/ml in groups E and L, respectively. Nociceptin was identified in 16/20 plasma samples with mean +/- SD concentrations of 7.59 +/- 21.58 and 13 73 +/- 23.79 pg/ml in groups E and L, respectively. CSF concentrations were significantly higher than plasma concentrations and there were no differences between groups E and L. These data report the first measurements of CSF nociceptin in man and show no association with the acute pain of labour. (C) 1998 International Association for the Study of Pain. Published by Elsevier Science B.V.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 08:37:42