Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
LITHIUM AND DESIPRAMINE VERSUS DESIPRAMINE ALONE IN THE TREATMENT OF SEVERE MAJOR DEPRESSION - A PRELIMINARY-STUDY
Autore:
CAPPIELLO A; MCDOUGLE CJ; DELGADO PL; MALISON RT; JATLOW P; CHARNEY DS; HENINGER GR; PRICE LH;
Indirizzi:
BROWN UNIV,SCH MED,DEPT PSYCHIAT & HUMAN BEHAV,BUTLER HOSP,345 BLACKSTONE BLVD PROVIDENCE RI 02906 CONNECTICUT MENTAL HLTH CTR,ABRAHAM RIBICOFF RES FACIL,CLIN NEUROSCI RES UNIT NEW HAVEN CT 06519 YALE UNIV,SCH MED,DEPT PSYCHIAT NEW HAVEN CT 00000 YALE UNIV,SCH MED,DEPT LAB MED NEW HAVEN CT 06510
Titolo Testata:
International clinical psychopharmacology
fascicolo: 5, volume: 13, anno: 1998,
pagine: 191 - 198
SICI:
0268-1315(1998)13:5<191:LADVDA>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
TREATMENT-RESISTANT DEPRESSION; REFRACTORY DEPRESSION; DOUBLE-BLIND; TRICYCLIC ANTIDEPRESSANTS; RAPID RESPONSE; AUGMENTATION; CARBONATE; TRIAL; COMBINATION; TRANYLCYPROMINE;
Keywords:
DESIPRAMINE; LITHIUM; MAJOR DEPRESSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
47
Recensione:
Indirizzi per estratti:
Citazione:
A. Cappiello et al., "LITHIUM AND DESIPRAMINE VERSUS DESIPRAMINE ALONE IN THE TREATMENT OF SEVERE MAJOR DEPRESSION - A PRELIMINARY-STUDY", International clinical psychopharmacology, 13(5), 1998, pp. 191-198

Abstract

Improvement following lithium augmentation is well-documented in depressed patients resistant to tricyclic antidepressants. However, response latency to lithium augmentation is extremely variable, suggesting other mechanisms may be involved. To evaluate whether long-term tricyclic treatment is necessary for lithium augmentation's effect, the rapidity and magnitude of response to lithium combined with desipramine from the start of treatment was compared to desipramine alone in severelydepressed patients. Patients with DSM-III-R major depression were randomized to double-blind, placebo-controlled treatment with either lithium + desipramine or placebo + desipramine for 4 weeks. Response criteria were based on Hamilton Depression Rating Scale scores and global improvement. Analysis of covariance of Hamilton scores demonstrated that lithium + desipramine was superior to placebo + desipramine at week 1 (P < 0.009), week 2 (P < 0.028), and week 3 (P < 0.07), although notat week 4. There were more responders to the combination than to monotherapy (P < 0.042). These preliminary data suggest that lithium + desipramine may have some efficacy in severely depressed patients. Further studies with larger samples are needed to confirm these findings. Int Clin Psychopharmacol 13:191-198 (C) 1998 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 03:53:27