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Titolo:
LOW-CALCIUM ABOLISHES TIP LINKS AND ALTERS RELATIVE STEREOCILIA MOTION IN CHICK COCHLEAR HAIR-CELLS
Autore:
DUNCAN RK; DYCE OH; SAUNDERS JC;
Indirizzi:
UNIV PENN,DEPT OTORHINOLARYNGOL HEAD & NECK SURG,5 RAVDIN-ORL,3400 SPRUCE ST PHILADELPHIA PA 19104 UNIV PENN,DEPT OTORHINOLARYNGOL HEAD & NECK SURG PHILADELPHIA PA 19104 UNIV PENN,DEPT BIOENGN PHILADELPHIA PA 19104
Titolo Testata:
Hearing research
fascicolo: 1-2, volume: 124, anno: 1998,
pagine: 69 - 77
SICI:
0378-5955(1998)124:1-2<69:LATLAA>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
MECHANOELECTRICAL TRANSDUCTION CHANNELS; GUINEA-PIG COCHLEA; INNER-EAR; CROSS-LINKS; BUNDLE; STIFFNESS; ORGANIZATION; DISPLACEMENT; INTEGRITY; MODEL;
Keywords:
AUDITORY; CHICK; STEREOCILIUM; MICROMECHANICS; CALCIUM; TIP LINK;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
R.K. Duncan et al., "LOW-CALCIUM ABOLISHES TIP LINKS AND ALTERS RELATIVE STEREOCILIA MOTION IN CHICK COCHLEAR HAIR-CELLS", Hearing research, 124(1-2), 1998, pp. 69-77

Abstract

The role of stereocilia tip links in controlling hair bundle motion on chick hair cells was examined in this study. Hair cells from the apical end of the basilar papilla were maintained in culture medium and oriented so that the sensory hair bundles were viewed in profile. A water-jet was used to stimulate the hair bundle and stroboscopic illumination allowed slow motion viewing of sensory hair motion at the bundle edges. Motion of the tallest stereocilium in the bundle was set to a criterion angular deflection and the excursion of the shortest stereocilium was measured. These measurements were made in a sample of hair cells maintained in culture medium containing either near normal levels of calcium or very low calcium levels supplemented with EGTA. In low calcium the angular deflection of the shortest hair was significantly reduced from that observed in normal media. The resting inward tilt of the hairs in the bundle, however, did not change. Scanning electron microscopy verified an almost complete destruction of tip links after exposure to low calcium. These results suggest that tip links contributesignificantly to the relative motion of stereocilia and exhibit the mechanical properties of a relatively stiff linkage. (C) 1998 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/09/20 alle ore 16:17:16