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Titolo:
PARALLEL COMPARATIVE TRIAL OF AMLODIPINE AND NITRENDIPINE MONOTHERAPYIN PATIENTS WITH ESSENTIAL-HYPERTENSION
Autore:
WANG XY; GONG LS; GUO JZ; WANG XM; LIU YH; YE XY; ZHANG GY; YANG PL;
Indirizzi:
SHANGHAI MED UNIV 2,RUI JIN HOSP,SHANGHAI INST HYPERTENS SHANGHAI 200025 PEOPLES R CHINA DALIAN MED COLL,HOSP 2 DALIAN PEOPLES R CHINA MIL MED COLL 2,CHANZHENG HOSP SHANGHAI PEOPLES R CHINA SSMU,HOSP 9 SHANGHAI PEOPLES R CHINA
Titolo Testata:
Journal of hypertension
, volume: 16, anno: 1998, supplemento:, 4
pagine: 43 - 47
SICI:
0263-6352(1998)16:<43:PCTOAA>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Keywords:
ESSENTIAL HYPERTENSION; AMLODIPINE; NITRENDIPINE; AMBULATORY BLOOD PRESSURE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
13
Recensione:
Indirizzi per estratti:
Citazione:
X.Y. Wang et al., "PARALLEL COMPARATIVE TRIAL OF AMLODIPINE AND NITRENDIPINE MONOTHERAPYIN PATIENTS WITH ESSENTIAL-HYPERTENSION", Journal of hypertension, 16, 1998, pp. 43-47

Abstract

Objectives To compare the blood pressure effects of two dihydropyridine calcium channel blockers, amlodipine and nitrendipine, in 488 patients with essential hypertension. Methods The study used a randomized, single-blind design of 4 weeks' duration conducted at four medical centres in China Patients were randomized to receive either amlodipine monotherapy (5-10 mg once daily; n = 334) or nitrendipine (10 mg twice or three times daily; n = 154). Blood pressure was evaluated by standard blood pressure measurements before and after treatment, and by 24 h ambulatory blood pressure monitoring in a subgroup of patients (n = 18). Results Both systolic and diastolic blood pressures were reduced from baseline after 4 weeks of amlodipine and nitrendipine monotherapy. Diastolic blood pressure was reduced by 14.4% in the amlodipine group,which was significantly better than the 13.0% reduction in the nitrendipine group (P< 0.05), In addition, blood pressure response rates were significantly better with amlodipine monotherapy than with nitrendipine monotherapy. In the subgroup of patients undergoing 24 h ambulatory blood pressure monitoring, both systolic and diastolic blood pressure were reduced from baseline in the amlodipine and nitrendipine groups. Adverse effects were generally mild, with dizziness, flushing, palpitation, headache, drowsiness and ankle oedema being the most common. Flushing and headache were more frequent in the nitrendipine group thanin the amlodipine group (P< 0.05 for flushing and P<0.01 for headache). Conclusions Amlodipine monotherapy reduced blood pressure more effectively than nitrendipine monotherapy in patients with essential hypertension and was associated with fewer adverse events. J Hypertens 16 (suppl 4):S43-S47 (C) 1998 Lippincott Williams & Wilkins

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 10:09:39