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Titolo:
NITRIC OXIDE-DEPENDENT VASODILATION IN YOUNG SPONTANEOUSLY HYPERTENSIVE RATS
Autore:
RADAELLI A; MIRCOLI L; MORI I; MANCIA G; FERRARI AU;
Indirizzi:
UNIV MILAN,CTR FISIOL CLIN & IPERTENS,CATTEDRA CARDIOANGIOL MED,VIA FSFORZA 35 I-20122 MILAN ITALY UNIV MILAN,CTR FISIOL CLIN & IPERTENS,CATTEDRA CARDIOANGIOL MED I-20122 MILAN ITALY UNIV MILAN,OSPED MAGGIORE MILAN ITALY OSPED SAN GERARDO,CATTEDRA MED INTERNA MONZA ITALY AZ OSP CIV,OSPED SEREGNO,DIV CARDIORIABILITAZ VIMERCATE ITALY
Titolo Testata:
Hypertension
fascicolo: 4, volume: 32, anno: 1998,
pagine: 735 - 739
SICI:
0194-911X(1998)32:4<735:NOVIYS>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
MONOMETHYL-L-ARGININE; SKELETAL-MUSCLE ARTERIOLES; IN-VIVO; ENDOTHELIUM; ACETYLCHOLINE; RESPONSES; ARTERY; RELAXATION; INHIBITION; STRESS;
Keywords:
NITRIC OXIDE; RATS, INBRED SHR; VASCULAR REACTIVITY; L-NAME; HEXAMETHONIUM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
A. Radaelli et al., "NITRIC OXIDE-DEPENDENT VASODILATION IN YOUNG SPONTANEOUSLY HYPERTENSIVE RATS", Hypertension, 32(4), 1998, pp. 735-739

Abstract

Conflicting evidence exists on the possible impairment of tonic nitric oxide (NO)-mediated vasodilation as a causative factor in the genesis of human as well as experimental hypertension. We evaluated the tonic NO-dependent vasodilation from the presser response to NO synthesis inhibition by N-G-monomethyl-L-arginine (L-NMMA) in 9 conscious, chronically instrumented spontaneously hypertensive rats (SHR) at 12 weeks of age, ie, during the early established hypertensive stage. Nine age-matched Wistar-Kyoto rats (WKY) were used as controls. The presser responses to L-NMMA (100 mg . kg(-1) IV bolus plus 1.5 mg . kg(-1) . min(-1) infusion for 60 minutes) as well as to non-NO-dependent presser stimuli, namely, vasopressin (2, 4, and 8 ng . kg(-1)) and phenylephrine(0.5, 1, and 2 mu g . kg(-1)) given as IV boluses, were assessed bothunder control conditions and during suppression of autonomic reflexesby hexamethonium (30 mg . kg(-1) IV bolus+1.5 mg . kg(-1) min-L infusion). Rather than being reduced, the presser responses to L-NMMA were 39% and 71% larger in the control and areflexic conditions, respectively, than those observed in WKY (both P<0.01). A similar pattern was observed for the presser responses to vasopressin (f37% and +68% in the control and areflexic conditions, respectively; both P<0.01) and phenylephrine, (+20% and +52%; both P<0.05). Additional groups of 6-week-old prehypertensive SHR (n=11) and age-matched WKY (n=11) were subjectedto an identical protocol: in these animals, the presser responses to L-NMMA were similar in each strain, as were the presser responses to vasopressin and phenylephrine in both control and areflexic conditions. In conclusion, our observations indicate that during the developmental phase of hypertension in the SHR model, namely, during the prehypertensive as well as the early established hypertensive stage, NO-dependent vasodilation is preserved (if not enhanced) so that a putative impairment of this function provides no significant pathogenic contribution to the onset of hypertension in this experimental model.

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Documento generato il 22/09/20 alle ore 08:06:01