Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
ISOLATION OF A CHROMOSOME-1 REGION THAT CONTRIBUTES TO HIGH BLOOD-PRESSURE AND SALT SENSITIVITY
Autore:
IWAI N; TSUJITA Y; KINOSHITA M;
Indirizzi:
SHIGA UNIV MED SCI,DEPT INTERNAL MED 1 OTSU SHIGA 52021 JAPAN
Titolo Testata:
Hypertension
fascicolo: 4, volume: 32, anno: 1998,
pagine: 636 - 638
SICI:
0194-911X(1998)32:4<636:IOACRT>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
SPONTANEOUSLY HYPERTENSIVE RAT; GENE; KIDNEYS; LOCI;
Keywords:
BLOOD PRESSURE; RATS, INBRED SHR; GENETICS; CONGENIC STRAIN; CHROMOSOME 1;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
16
Recensione:
Indirizzi per estratti:
Citazione:
N. Iwai et al., "ISOLATION OF A CHROMOSOME-1 REGION THAT CONTRIBUTES TO HIGH BLOOD-PRESSURE AND SALT SENSITIVITY", Hypertension, 32(4), 1998, pp. 636-638

Abstract

Linkage analyses in the spontaneously hypertensive rat (SHR) suggest that a gene involved in blood pressure regulation may be located on rat chromosome 1, in the Sn region. To confirm this possibility, we replaced a region of chromosome 1 in the Wistar-Kyoto rat (WKY) defined bythe markers D1Mit3 and MTPA with the corresponding chromosome segmentfrom SHR. Genotyping using 65 polymorphic microsatellite markers throughout the entire genome confirmed the congenic status of this new strain designated WKY.SHR-D1Mit3/Rat57. In male WKY.SHR-D1Mit3/Rat57, mean blood pressures in the daytime and in the nighttime assessed by radiotelemetry were significantly higher than those in male progenitor WKY. Moreover, salt loading significantly increased the mean blood pressure in male WKY.SHR-D1Mit3/Rat57 but not in male progenitor WKY. The present study confirmed the existence of a gene that contributes to highblood pressure and salt sensitivity in this chromosomal segment. Thiscongenic strain represents a new animal model for fine mapping and characterization of the gene in this region involved in salt-sensitive hypertension.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/07/20 alle ore 08:00:20