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Titolo:
ULTRASTRUCTURAL EXAMINATION OF CORNEAL EPITHELIUM OF SPONTANEOUSLY OBESE, HYPERGLYCEMIC RATS
Autore:
SAIKA S; SHIMEZAKI M; OHKAWA K; OKADA Y; TAWARA A; OHNISHI Y; OOSHIMA A; KIMURA M; KURUMATANI N; NAKA H; AWATA T; KAO WWY;
Indirizzi:
UNIV CINCINNATI,MED CTR,DEPT OPHTHALMOL,HLTH PROFESS BLDG,SUITE 350,ML 0527,EDEN & BETHES CINCINNATI OH 45267 WAKAYAMA MED COLL,DEPT OPHTHALMOL WAKAYAMA 640 JAPAN WAKAYAMA MED COLL,DEPT PATHOL WAKAYAMA 640 JAPAN KANSAI SHINKYU COLL,DEPT ANAT OSAKA JAPAN
Titolo Testata:
Current eye research (Print)
fascicolo: 11, volume: 17, anno: 1998,
pagine: 1049 - 1057
SICI:
0271-3683(1998)17:11<1049:UEOCEO>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN-KINASE-C; REDUCTASE INHIBITOR CT-112; ALDOSE REDUCTASE; DIABETIC RATS; BASEMENT-MEMBRANE; COMPLICATIONS; EXPRESSION; ACTIVATION; ELEVATION; MECHANISM;
Keywords:
HYPERGLYCEMIA; OTSUKA LONG-EVANS TOKUSHIMA FATTY RAT; CORNEAL EPITHELIUM; ULTRASTRUCTURE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
S. Saika et al., "ULTRASTRUCTURAL EXAMINATION OF CORNEAL EPITHELIUM OF SPONTANEOUSLY OBESE, HYPERGLYCEMIC RATS", Current eye research (Print), 17(11), 1998, pp. 1049-1057

Abstract

Purpose. Otsuka Long-Evans Tokushima fatty (OLETF) rats spontaneouslybecome obese and hyperglycemic with age. We investigated whether the development of hyperglycemia would alter the ultrastructure of the corneal epithelium. Methods. Scanning and transmission electron microscopy (SEM and TEM) were used to examine the morphology of corneal epithelial cells. Fourteen OLETF rats were evaluated, and 9 Long-Evans Tokushima Otsuka (LETO) rats were used as control. Non-hyperglycemic OLETF rats served as controls. Results. SEM showed exfoliative changes in thesurface of the central corneal epithelium of the hyperglycemic OLETF rats. These superficial epithelial cells were irregular in shape as compared to polygonal shapes of those of LETO and non-hyperglycemic OLETF rats. The mean anterior surface area of individual superficial epithelial cells was significantly smaller in the hyperglycemic OLETF than that of the LETO or the non-hyperglycemic OLETF rats. Central protrusion(s) could be found in some of the superficial cells of all rats examined, although this phenomenon was more common in the hyperglycemic rats than in the non-hyperglycemic rats. TEM revealed that there were numerous cytoplasmic vacuoles and wide intercellular spaces in the central corneal epithelium of the hyperglycemic OLETF rats, but not in the non-hyperglycemic rats. Conclusions. The development of spontaneous hyperglycemia in OLETF rats alters the ultrastructure of the corneal epithelium. The alterations included abnormalities of the corneal epithelial surface observed by SEM and the presence of intracellular vacuolesand enlarged intercellular spaces detected by TEM.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 21:41:51