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Titolo:
THE 2 FUNCTIONAL KERATIN-6 GENES OF MOUSE ARE DIFFERENTIALLY REGULATED AND EVOLVED INDEPENDENTLY FROM THEIR HUMAN ORTHOLOGS
Autore:
TAKAHASHI K; YAN B; YAMANISHI K; IMAMURA S; COULOMBE PA;
Indirizzi:
JOHNS HOPKINS UNIV,SCH MED,DEPT BIOL CHEM,725 N WOLFE ST BALTIMORE MD21205 JOHNS HOPKINS UNIV,SCH MED,DEPT BIOL CHEM BALTIMORE MD 21205 JOHNS HOPKINS UNIV,SCH MED,DEPT DERMATOL BALTIMORE MD 21205 KYOTO UNIV,GRAD SCH MED,DEPT DERMATOL KYOTO 606 JAPAN KYOTO PREFECTURAL UNIV MED,DEPT DERMATOL KYOTO JAPAN
Titolo Testata:
Genomics (San Diego, Calif.)
fascicolo: 2, volume: 53, anno: 1998,
pagine: 170 - 183
SICI:
0888-7543(1998)53:2<170:T2FKGO>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
STRATIFIED SQUAMOUS EPITHELIA; PACHYONYCHIA-CONGENITA; INTERMEDIATE FILAMENTS; TRANSGENIC MICE; TRANSCRIPTION FACTORS; CYTOKERATIN GENES; CULTURED-CELLS; EXPRESSION; SKIN; EVOLUTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
50
Recensione:
Indirizzi per estratti:
Citazione:
K. Takahashi et al., "THE 2 FUNCTIONAL KERATIN-6 GENES OF MOUSE ARE DIFFERENTIALLY REGULATED AND EVOLVED INDEPENDENTLY FROM THEIR HUMAN ORTHOLOGS", Genomics (San Diego, Calif.), 53(2), 1998, pp. 170-183

Abstract

The type II keratin 6 (K6) features a complex expression pattern, with a constitutive component in a subset of stratified epithelia and an inducible component following injury and other types of acute challenges. Multiple genes encoding highly related K6 isoforms have been described for human and bovine, a unique feature among mammalian keratin genes. Here we report on the cloning and characterization of two functional genes and their cDNAs encoding the K6 isoforms in mouse and two related pseudogenes. A systematic comparison of the mouse and human K6 genes suggests that they evolved independently after these species diverged. The mK6 alpha and mK6 beta genes are organized in tandem with the same transcriptional orientation in the mouse genome. Similar to thehuman isoforms, the coding sequences for mK6 alpha and mK6 beta isoforms show similar to 95% identity. The two mouse K6 genes are differentially regulated at the mRNA level in several stratified epithelia. ThemK6 alpha isoform mRNA clearly predominates in intact trunk skin of adult mice, where it is restricted to the outer root sheath of hair follicles. Both mRNAs are induced in epidermis and proximal hair follicles as early as 1 h following acute injury or topical application of phorbol esters and subsequently increase to a comparable extent but with different kinetics. These novel findings have important implications for the evolution, regulation, and function of K6 genes in mammalian species. (C) 1998 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 08:12:49