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Titolo:
COMBINATION OF OPEN-FIELD AND ELEVATED PLUS-MAZE - A SUITABLE TEST BATTERY TO ASSESS STRAIN AS WELL AS TREATMENT DIFFERENCES IN RAT BEHAVIOR
Autore:
SCHMITT U; HIEMKE C;
Indirizzi:
UNIV MAINZ,DEPT PSYCHIAT,UNTERE ZAHLBACHER STR 8 D-55101 MAINZ GERMANY UNIV MAINZ,DEPT PSYCHIAT D-55101 MAINZ GERMANY
Titolo Testata:
Progress in neuro-psychopharmacology & biological psychiatry
fascicolo: 7, volume: 22, anno: 1998,
pagine: 1197 - 1215
SICI:
0278-5846(1998)22:7<1197:COOAEP>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERINATAL FLUMAZENIL; ANXIETY; MICE; EMOTIONALITY; DIAZEPAM; BENZODIAZEPINES; STIMULATION; AVOIDANCE; SUBUNIT; AGENTS;
Keywords:
ELEVATED PLUS-MAZE; ENRICHED OPEN-FIELD; HANDLING; OPEN-FIELD; RAT STRAINS; TRANQUILIZER;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
39
Recensione:
Indirizzi per estratti:
Citazione:
U. Schmitt e C. Hiemke, "COMBINATION OF OPEN-FIELD AND ELEVATED PLUS-MAZE - A SUITABLE TEST BATTERY TO ASSESS STRAIN AS WELL AS TREATMENT DIFFERENCES IN RAT BEHAVIOR", Progress in neuro-psychopharmacology & biological psychiatry, 22(7), 1998, pp. 1197-1215

Abstract

1. A test battery consisting of a standard open field, an enriched open field and an elevated plus maze was used to study behavior in rats.2. Male rats of the strains PVG/OlaHsd (PVG) and Sprague-Dawely-Hsd (SPRD) (150-200g body wt) were used to assess interstrain differences as well as handling effects. In a subsequent experiment an other set ofmale PVG rats (150-200g body wt) treated either with diazepam or zolpidem was used to evaluate the test battery for pharmacological purposes. 3. SPRD rats displayed higher motor activity levels and also higherlevels of exploratory behavior than the PVG rats. In contrast plus-maze activity indicated more anxiety of SPRD than PVG rats. One week pre-test handling increased the activity of both strains but it increasedexplorative behavior in the enriched open field only in SPRD rats. Diazepam had a substantial anxiolytic effect. Zolpidem enhanced the explorative activity in a differently to diazepam and exerted only minor anxiolytic properties. 4. We concluded that the test battery used here enables to reveal differentially strain, and treatment effects in rats.

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Documento generato il 17/02/20 alle ore 17:20:43