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Titolo:
CHRONICAL HALOPERIDOL AND CLOZAPINE TREATMENT IN RATS - DIFFERENTIAL RNA DISPLAY ANALYSIS, BEHAVIORAL-STUDIES AND SERUM LEVEL DETERMINATION
Autore:
FISCHER V; SCHMITT U; WEIGMANN H; VONKELLER B; REUSS S; HIEMKE C; DAHMEN N;
Indirizzi:
UNIV MAINZ,DEPT PSYCHIAT,UNTERE ZAHLBACHERSTR 8 D-55131 MAINZ GERMANY UNIV MAINZ,DEPT PSYCHIAT D-55131 MAINZ GERMANY UNIV MAINZ,DEPT ANAT D-55131 MAINZ GERMANY
Titolo Testata:
Progress in neuro-psychopharmacology & biological psychiatry
fascicolo: 7, volume: 22, anno: 1998,
pagine: 1129 - 1139
SICI:
0278-5846(1998)22:7<1129:CHACTI>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
CLINICAL-RESPONSE; MESSENGER-RNA; SCHIZOPHRENIA; EXPRESSION; PLASMA; ANTIPSYCHOTICS; METABOLITES; TURNOVER; CLONING; INVIVO;
Keywords:
BEHAVIORAL STUDIES; CHRONICAL TREATMENT; CLOZAPINE; DIFFERENTIAL RNA DISPLAY; HALOPERIDOL;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
V. Fischer et al., "CHRONICAL HALOPERIDOL AND CLOZAPINE TREATMENT IN RATS - DIFFERENTIAL RNA DISPLAY ANALYSIS, BEHAVIORAL-STUDIES AND SERUM LEVEL DETERMINATION", Progress in neuro-psychopharmacology & biological psychiatry, 22(7), 1998, pp. 1129-1139

Abstract

1. Adult, female rats were treated orally for 23 days with 1.6 mg/kg haloperidol or 36 mg/kg clozapine per day, to study chronic effects ofthe two neuroleptics. 2. At five time points during the neuroleptic treatment, animal behavior was recorded in an open field and locomotiveactivity was analysed. At the end of the experiment, rats were decapitated, blood samples were collected and serum concentrations of haloperidol and clozapine were determined by a radioreceptor or HPLC assay, respectively. RNA was isolated from each brain, without cerebellum, and subjected to differential RNA display. 3. Mean serum concentrations were 8 ng/ml for haloperidol smd 21 ng/ml for clozapine. Analysis of open field behavior showed that haloperidol and clozapine decreased thetotal distance moved and the velocity as measures of the overall activity, whereas the number of rearings and the number of entries into the center, reflecting risk assessment behavior, were differentially affected. Three neuroleptic-regulated gene fragment bands were identifiedin differential RNA display experiments. Two gene fragments of 281 bpand 266 bp. were sequenced. 4. We conclude that our study design thatused behavioral, pharmacokinetic and molecular analysis increase the likelihood of finding relevant molecular events underlying the pharmacotherapeutic effects of neuroleptics in animal models.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 06:31:15