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Titolo:
COORDINATED AND CELL-SPECIFIC REGULATION OF MEMBRANE TYPE MATRIX METALLOPROTEINASE 1 (MT1-MMP) AND ITS SUBSTRATE MATRIX METALLOPROTEINASE 2(MMP-2) BY PHYSIOLOGICAL SIGNALS DURING FOLLICULAR DEVELOPMENT AND OVULATION
Autore:
LIU K; WAHLBERG P; NY T;
Indirizzi:
UMEA UNIV,DEPT MED BIOCHEM & BIOPHYS S-90187 UMEA SWEDEN UMEA UNIV,DEPT MED BIOCHEM & BIOPHYS S-90187 UMEA SWEDEN
Titolo Testata:
Endocrinology
fascicolo: 11, volume: 139, anno: 1998,
pagine: 4735 - 4738
SICI:
0013-7227(1998)139:11<4735:CACROM>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
MESSENGER-RIBONUCLEIC-ACID; PRO-GELATINASE-A; PLASMINOGEN ACTIVATORS; PERIOVULATORY PERIOD; EXTRACELLULAR-MATRIX; EXPRESSION; TISSUE; RAT; METASTASIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
K. Liu et al., "COORDINATED AND CELL-SPECIFIC REGULATION OF MEMBRANE TYPE MATRIX METALLOPROTEINASE 1 (MT1-MMP) AND ITS SUBSTRATE MATRIX METALLOPROTEINASE 2(MMP-2) BY PHYSIOLOGICAL SIGNALS DURING FOLLICULAR DEVELOPMENT AND OVULATION", Endocrinology, 139(11), 1998, pp. 4735-4738

Abstract

In the ovary, extensive tissue remodeling is required during both follicular development and the break down of the follicular wall at the time of ovulation. Extracellular proteases such as serine proteases andmatrix metalloproteinases (MMPs) are thought to play pivotal roles inthese processes. In this paper, we have used in situ hybridization tostudy the regulation and distribution of mRNA coding for MMP-2 (gelatinase A) and its cell surface activator membrane-type MMPI (MT1-MMP) during gonadotropin induced ovulation in the rat. In ovaries of untreated immature (23 day old) rats, the levels of MT1-MMP and MMP-2 mRNA were low. MMP-2 mRNA was found in theca-interstitial cells while MT1-MMPmRNA was found in both granulosa and theca-interstitial cells and both messages were induced after stimulation with PMSG. After an ovulatory dose of hCG, the expression of MT1-MMP was dramatically down regulated in the granulosa cell layers of large preovulatory follicles but the expression remained and appeared to be up regulated together with MMP-2 in the theca-interstitial cells surrounding the large preovulatoryfollicles. The expression kinetics and tissue distribution supports the notion that MT1-MMP may have dual functions in the ovary. InitiallyMT1-MMP may act as a matrix degrading protease inside the follicle during follicular development and later, just prior to ovulation, as an activator of proMMP-2 in theca-interstitial cells surrounding preovulatory follicles.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 16:01:24