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Titolo:
HYPERPHAGIA AND WEIGHT-GAIN AFTER GOLD-THIOGLUCOSE - RELATION TO HYPOTHALAMIC NEUROPEPTIDE-Y AND PROOPIOMELANOCORTIN
Autore:
BERGEN HT; MIZUNO TM; TAYLOR J; MOBBS CV;
Indirizzi:
UNIV MANITOBA,DEPT HUMAN ANAT & CELL SCI,730 WILLIAM AVE WINNIPEG MB R3E 0W3 CANADA CUNY MT SINAI SCH MED,FISHBERG CTR NEUROBIOL NEW YORK NY 10029
Titolo Testata:
Endocrinology
fascicolo: 11, volume: 139, anno: 1998,
pagine: 4483 - 4488
SICI:
0013-7227(1998)139:11<4483:HAWAG->2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
AGOUTI OBESITY SYNDROME; MESSENGER-RNA; MONOSODIUM GLUTAMATE; GENE-EXPRESSION; ARCUATE NUCLEUS; OB/OB MICE; LEPTIN; INDUCTION; RECEPTOR; GLUCOSE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
47
Recensione:
Indirizzi per estratti:
Citazione:
H.T. Bergen et al., "HYPERPHAGIA AND WEIGHT-GAIN AFTER GOLD-THIOGLUCOSE - RELATION TO HYPOTHALAMIC NEUROPEPTIDE-Y AND PROOPIOMELANOCORTIN", Endocrinology, 139(11), 1998, pp. 4483-4488

Abstract

Genetic obesity is associated with increased neuropeptide Y (NPY) messenger RNA (mRNA) and decreased POMC mRNA in the hypothalamus of ob lob and db / db mice, or impaired sensitivity to alpha MSH (derived fromPOMC) in the yellow agouti mouse. Acquired obesity can be produced bychemically lesioning the hypothalamus with either monosodium glutamate (MSG) in neonates or gold thioglucose (GTG) in adult mice. The present study examined whether elevated NPY mRNA and/or decreased POMC mRNAin the hypothalamus are associated with obesity due to hypothalamic lesions. GTG injection into adult mice produced a profound obese phenotype, including hyperphagia, increased body weight, and increased leptin mRNA and peptide, in association with reduced hypothalamic NPY mRNA and POMC mRNA. MSG treatment produced virtual elimination of NPY mRNA in the arcuate nucleus and a reduction of hypothalamic POMC mRNA, and led to elevated leptin. MSG pretreatment did not attenuate GTG-inducedhyperphagia and obese phenotype. These results do not support a role for NPY-synthesizing neurons in the arcuate nucleus in mediating hypothalamic acquired obesity, but are consistent with the hypothesis that decreased activity of hypothalamic neurons synthesizing POMC play a role in mediating hypothalamic obesity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/08/20 alle ore 21:04:58