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Titolo:
BIARYL ACIDS - NOVEL NONNUCLEOSIDE INHIBITORS OF HIV REVERSE-TRANSCRIPTASE TYPES 1 AND 2
Autore:
MILTON J; SLATER MJ; BIRD AJ; SPINKS D; SCOTT G; PRICE CE; DOWNING S; GREEN DVS; MADAR S; BETHELL R; STAMMERS DK;
Indirizzi:
GLAXOWELLCOME MED RES CTR,DEPT CHEM,GUNNELS WOOD RD STEVENAGE SG1 2NYHERTS ENGLAND GLAXOWELLCOME MED RES CTR,DEPT CHEM STEVENAGE SG1 2NY HERTS ENGLAND GLAXOWELLCOME MED RES CTR,DEPT BIOMOL STRUCT STEVENAGE SG1 2NY HERTS ENGLAND GLAXOWELLCOME MED RES CTR,DEPT ENZYME PHARMACOL STEVENAGE SG1 2NY HERTS ENGLAND UNIV OXFORD,LAB MOL BIOPHYS OXFORD OX1 3QU ENGLAND
Titolo Testata:
Bioorganic & medicinal chemistry letters
fascicolo: 19, volume: 8, anno: 1998,
pagine: 2623 - 2628
SICI:
0960-894X(1998)8:19<2623:BA-NNI>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
INFECTIONS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
9
Recensione:
Indirizzi per estratti:
Citazione:
J. Milton et al., "BIARYL ACIDS - NOVEL NONNUCLEOSIDE INHIBITORS OF HIV REVERSE-TRANSCRIPTASE TYPES 1 AND 2", Bioorganic & medicinal chemistry letters, 8(19), 1998, pp. 2623-2628

Abstract

A series of biaryl acids has been found to show micromolar inhibitionof the HIV reverse transcriptase (RT) from types 1 and 2 with IC(50)sin the micromolar range. The series was discovered by consideration of the polymerase active site and sub-structure searching of the company compound collection. Synthesis of analogues to investigate the SAR is described. Two of these compounds have shown inhibition of HIV-2 RT only. (C) 1998 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 13:13:57