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Titolo:
ISOCRATIC HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY FOR THE SIMULTANEOUSSEPARATION OF 11 TRICYCLIC IMIPRAMINE-DERIVED COMPOUNDS OF THERAPEUTIC INTEREST
Autore:
JOSEPHCHARLES J; BERTUCAT M;
Indirizzi:
FAC PHARM,LAB CHIM ANALYT APPL,3 TER PL VICTOIRE F-33076 BORDEAUX FRANCE
Titolo Testata:
Journal of liquid chromatography & related technologies
fascicolo: 19, volume: 21, anno: 1998,
pagine: 3047 - 3064
SICI:
1082-6076(1998)21:19<3047:IHLFTS>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
SOLID-PHASE EXTRACTION; HUMAN PLASMA; HUMAN SERUM; ULTRAVIOLET DETECTION; N-DESMETHYLCLOZAPINE; CLOZAPINE; PIRENZEPINE; METABOLITES; DRUGS; ASSAY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
J. Josephcharles e M. Bertucat, "ISOCRATIC HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY FOR THE SIMULTANEOUSSEPARATION OF 11 TRICYCLIC IMIPRAMINE-DERIVED COMPOUNDS OF THERAPEUTIC INTEREST", Journal of liquid chromatography & related technologies, 21(19), 1998, pp. 3047-3064

Abstract

A rapid, specific, and sensitive high performance liquid chromatographic method for the simultaneous analysis of eleven tricyclic imipramine-derived drugs has been developed by using a Lichrosorb RP Select B column, an isocratic system at ambient temperature, and UV detection at230 nm The influence of acetonitrile and methanol content, the molarity of sodium acetate, and the effect of adding counter-ion in the mobile phase have been investigated. Excellent separation of a mixture of the eleven compounds was accomplished within 30 minutes. The method was applied to pharmaceutical dosage forms containing a single active ingredient; any of the other compounds can be used as internal standard since these drugs are structural analogues and are generally not foundsimultaneously. Satisfactory results were obtained both for the recovery and the coefficient of variation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 01:05:52