Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
DISCOVERY OF NOVEL SELECTIVE HYPOTENSIVE VASOPRESSIN PEPTIDES THAT EXHIBIT LITTLE OR NO FUNCTIONAL INTERACTIONS WITH KNOWN OXYTOCIN VASOPRESSIN RECEPTORS/
Autore:
CHAN WY; WO NC; STOEV S; CHENG LL; MANNING M;
Indirizzi:
CORNELL UNIV,COLL MED,DEPT PHARMACOL,1300 YORK AVE NEW YORK NY 10021 MED COLL OHIO,DEPT BIOCHEM & MOL BIOL TOLEDO OH 43614
Titolo Testata:
British Journal of Pharmacology
fascicolo: 4, volume: 125, anno: 1998,
pagine: 803 - 811
SICI:
0007-1188(1998)125:4<803:DONSHV>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
NITRIC-OXIDE; ARGININE-VASOPRESSIN; POTENT ANTAGONISTS; RENAL VASODILATION; CONSCIOUS DOGS; SEPTIC SHOCK; OXYTOCIN; RAT; MODULATION; DEFICIENCY;
Keywords:
SELECTIVE HYPOTENSIVE VASOPRESSIN ANALOG AGONISTS; HYPOTENSIVE VASOPRESSIN PEPTIDES; NITRIC OXIDE AND VASOPRESSIN ANALOGS; VASODILATING ACTION OF AVP;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
46
Recensione:
Indirizzi per estratti:
Citazione:
W.Y. Chan et al., "DISCOVERY OF NOVEL SELECTIVE HYPOTENSIVE VASOPRESSIN PEPTIDES THAT EXHIBIT LITTLE OR NO FUNCTIONAL INTERACTIONS WITH KNOWN OXYTOCIN VASOPRESSIN RECEPTORS/", British Journal of Pharmacology, 125(4), 1998, pp. 803-811

Abstract

1 Arginine-vasopressin (VP) has both vasoconstricting and vasodilating action. We report here the discovery of four novel selective hypotensive VP analogues: d(CH2)(5)[D-Tyr(Et)(2),Arg(3),Val(4)]AVP; d(CH2)(5)[D-Tyr(Et)(2), Lys(3),Val(4)]AVP and their iodinatable Tyr-NH29 analogues. 2 Bioassays in rats for activities characteristic of neurohypophysial peptides showed that the four VP peptides possessed little or no V-1a, V-2 or oxytocin (OT) receptor agonistic or antagonistic activities. 3 In anaesthetized rats, these peptides (0.05 - 0.10 mg kg(-1) i.v.) elicited a marked fall in arterial blood pressure. 4 Blockade of cholinoceptors, adrenoceptors and bradykinin B-2 receptors, and inhibition of prostaglandin synthesis had little effect on their vasodepressoraction. 5 Classical V-1a, V-2 and OT receptor antagonists did not block the vasodepressor response. 6 L-NAME, 0.2 mg kg(-1) min(-1), markedly suppressed the hypotensive response to ACh but not the vasodepressor response to the hypotensive VP peptides. However, the duration of the vasodepressor response was shortened. Very high doses of L-NAME attenuated both the vasodepressor response and the duration of action. 7 These findings indicate that the vasodepressor action of these VP peptides is independent of the peripheral autonomic, bradykinin and PG systems and is not mediated by the known classical OT/VP receptors. NO does not appear to have an important role in their vasodepressor action. 8 The discovery of these novel VP peptides could lead to the development of new tools for the investigation of the complex cardiovascular actions of VP and the introduction of a new class of hypotensive agents. The two iodinatable hypotensive VP peptides could be radiolabelled aspotential markers for the localization of the receptor system involved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 07:04:55