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Titolo:
THE RESPIRATORY BRONCHIOLE OF BEAGLE DOGS - STRUCTURAL CHARACTERISTICS
Autore:
TAKENAKA S; HEINI A; RITTER B; HEYDER J;
Indirizzi:
GSF FORSCHUNGSZENTRUM UMWELT & GESUNDHEIT,INST INHALAT BIOL,POB 1129 D-85758 NEUHERBERG GERMANY
Titolo Testata:
Toxicology letters
, volume: 96-7, anno: 1998,
pagine: 301 - 308
SICI:
0378-4274(1998)96-7:<301:TRBOBD>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
REGIONAL DEPOSITION; AIRWAYS; LUNGS; OZONE;
Keywords:
AIR POLLUTION; RESPIRATORY BRONCHIOLE; BEAGLE DOG;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
16
Recensione:
Indirizzi per estratti:
Citazione:
S. Takenaka et al., "THE RESPIRATORY BRONCHIOLE OF BEAGLE DOGS - STRUCTURAL CHARACTERISTICS", Toxicology letters, 96-7, 1998, pp. 301-308

Abstract

The centriacinar regions are a central site of lung diseases and theyare also considered to be susceptible to air pollutants. Dogs as wellas humans and monkeys possess several generations of respiratory bronchioles. Commonly used small laboratory animals, however, have either no, or at most, a single short generation. Therefore, it is assumed that the response to air pollutants differs among animal species according to the presence or absence of the respiratory bronchiole. Although the conducting airways and alveolar regions have been well examined, morphological details of the respiratory bronchiole remain to be elucidated. To better understand the architecture of the respiratory bronchiole, we investigated this region of beagle dogs by means of serial sections of paraffin tissues. This study shows that respiratory bronchioles of beagle dogs consist of up to five generations. Branching patterns of the respiratory bronchiole of beagle dogs were comparable to those of humans. The surface of the respiratory bronchiole is comprised ofthe bronchiolar epithelial lining and alveolar outpocketings. The lining cells of beagle dogs are mainly nonciliated cells (Clara cells) whereas ciliated cells are very rare. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 18:59:45