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Titolo:
THE FAMILY OF NA+ CL- NEUROTRANSMITTER TRANSPORTERS/
Autore:
NELSON N;
Indirizzi:
TEL AVIV UNIV,DEPT BIOCHEM IL-69978 TEL AVIV ISRAEL
Titolo Testata:
Journal of neurochemistry
fascicolo: 5, volume: 71, anno: 1998,
pagine: 1785 - 1803
SICI:
0022-3042(1998)71:5<1785:TFONCN>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
GAMMA-AMINOBUTYRIC-ACID; DOPAMINE-NOREPINEPHRINE TRANSPORTERS; PHENCYCLIDINE-INDUCED HYPERACTIVITY; MAMMALIAN SEROTONIN TRANSPORTER; BRAIN GABA TRANSPORTER; CENTRAL NERVOUS-SYSTEM; RAT-BRAIN; GLYCINE TRANSPORTER; MOUSE-BRAIN; MOLECULAR-CLONING;
Keywords:
NEUROTRANSMISSION; GAMMA-AMINOBUTYRIC ACID TRANSPORTERS; MONOAMINE TRANSPORTERS; AMINO ACID TRANSPORTERS; ORPHAN TRANSPORTERS; BACTERIAL TRANSPORTERS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
156
Recensione:
Indirizzi per estratti:
Citazione:
N. Nelson, "THE FAMILY OF NA+ CL- NEUROTRANSMITTER TRANSPORTERS/", Journal of neurochemistry, 71(5), 1998, pp. 1785-1803

Abstract

The termination of neurotransmission is achieved by rapid uptake of the released neurotransmitter by specific high-affinity neurotransmitter transporters. Most of these transporters are encoded by a family of genes (Na+/Cl- transporters) having a similar membrane topography of 12 transmembrane helices. An evolutionary tree revealed five distinct subfamilies: gamma-aminobutyric acid transporters, monoamine transporters, amino acid transporters, ''orphan'' transporters, and the recentlydiscovered bacterial transporters. The bacterial transporters that belong to this family may help to develop heterologous expression systems with the aim of solving the three-dimensional structure of these membrane proteins. Some of the neurotransmitter transporters have been implicated as important sites for drug action. Monoamine transporters, for example, are targeted by major classes of antidepressants, psychostimulants, and antihypertensive drugs. Localization of individual transporters in specific cells and brain areas is pertinent to understanding their contribution to neurotransmission and their potential as targets for drugs. The most important questions in the field include resolving the mechanism of neurotransmitter transport, the structure of the transporters, and the interaction of each transporter in complex neurological activities.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 18:45:16