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Titolo:
L-CANAVANINE IMPROVES ORGAN FUNCTION AND TISSUE ADENOSINE-TRIPHOSPHATE LEVELS IN RODENT ENDOTOXEMIA
Autore:
LIAUDET L; FISHMAN D; MARKERT M; PERRET C; FEIHL F;
Indirizzi:
UNIV LAUSANNE HOSP,INST PATHOPHYSIOL,BH 19-313 CH-1011 LAUSANNE SWITZERLAND UNIV LAUSANNE HOSP,INST PATHOPHYSIOL CH-1011 LAUSANNE SWITZERLAND UNIV LAUSANNE HOSP,CENT LAB CLIN CHEM LAUSANNE SWITZERLAND
Titolo Testata:
American journal of respiratory and critical care medicine
fascicolo: 5, volume: 155, anno: 1997,
pagine: 1643 - 1648
SICI:
1073-449X(1997)155:5<1643:LIOFAT>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
NITRIC-OXIDE SYNTHASE; SEPTIC SHOCK; MITOCHONDRIAL RESPIRATION; RAT; INHIBITION; SEPSIS; METABOLISM; FAILURE; LIVER; MACROPHAGES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
43
Recensione:
Indirizzi per estratti:
Citazione:
L. Liaudet et al., "L-CANAVANINE IMPROVES ORGAN FUNCTION AND TISSUE ADENOSINE-TRIPHOSPHATE LEVELS IN RODENT ENDOTOXEMIA", American journal of respiratory and critical care medicine, 155(5), 1997, pp. 1643-1648

Abstract

Overproduction of NO by an inducible NO synthase (iNOS) plays a majorrole in the pathophysiology of septic shock, and selective inhibitionof iNOS in this setting could be of great therapeutic value. In the present study, we evaluated the effects of L-canavanine, a selective iNOS inhibitor, in an animal model of septic shock, with a particular focus on tissue oxidative metabolism and organ functions. Anesthetized rats challenged intravenously with lipopolysacharide (LPS) were treatedafter 1 h by a continuous infusion of either L-canavanine (20 mg/kg/h; n = 11) or an equivalent volume of saline (2 ml/kg/h; n = 17) given for 4 h. A third group (sham rats; n = 9) did not receive LPS and was treated with a continuous infusion of saline (2 ml/kg/h). At the end of experiments, biopsies were taken from the liver, the kidney, and thesmall intestine for the measurement of tissue ATP. LPS induced a progressive fall in blood pressure, accompanied by biologic signs of liverand kidney failure, concomitant with a marked decrease in tissue ATP stores. L-canavanine largely prevented hypotension and significantly increased tissue ATP while reducing the signs of organ dysfunction. These effects were associated with a significant improvement in survival during the 5 h of study. We conclude that L-canavanine not only reduces hypotension in endotoxin shock but also largely prevents the detrimental consequences of LPS on tissue oxidative metabolism and major organ functions, allowing a decrease in endotoxin lethality.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/07/20 alle ore 07:35:46