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Titolo:
MINERALOCORTICOID RECEPTORS REGULATE BCL-2 AND P53 MESSENGER-RNA EXPRESSION IN HIPPOCAMPUS
Autore:
MCCULLERS DL; HERMAN JP;
Indirizzi:
UNIV KENTUCKY,ALBERT B CHANDLER MED CTR,DEPT ANAT & NEUROBIOL,800 ROSE ST LEXINGTON KY 40536
Titolo Testata:
NeuroReport
fascicolo: 13, volume: 9, anno: 1998,
pagine: 3085 - 3089
SICI:
0959-4965(1998)9:13<3085:MRRBAP>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM POTENTIATION; ACID-INDUCED SEIZURES; TUMOR-SUPPRESSOR P53; MESSENGER-RNA; RAT-BRAIN; PYRAMIDAL NEURONS; NERVOUS-SYSTEM; CELL-DEATH; BAX GENE; IN-VIVO;
Keywords:
CELL DEATH; GENES; MINERALOCORTICOID RECEPTORS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
D.L. Mccullers e J.P. Herman, "MINERALOCORTICOID RECEPTORS REGULATE BCL-2 AND P53 MESSENGER-RNA EXPRESSION IN HIPPOCAMPUS", NeuroReport, 9(13), 1998, pp. 3085-3089

Abstract

THE present study addressed the hypothesis that the neuronal mineralocorticoid receptor (MR) regulates genes associated with cell death, such as bar and p53, and cell viability, including bcl-2, BDNF, and NT-3. Rats were pretreated with either oil vehicle or the MR antagonist spironolactone (SPIRO) and subsequently injected with saline or kainic acid (KA). MR blockade significantly decreased basal mRNA expression ofbcl-2 in CA1 of saline-treated animals and attenuated KA-induced increases in p53 mRNA levels in CA3. SPIRO pretreatment had no significanteffect on expression of bar, NT-3, or BDNF mRNAs. The data suggest that the neuronal MR contributes to regulation of select cell survival and cell death-related genes in hippocampal pyramidal neurons. NeuroReport 9: 3085-3089 (C) 1998 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 22:52:05