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Titolo:
EFFECTS OF CLOPIDOGREL, ASPIRIN AND COMBINED THERAPY IN A PORCINE EX-VIVO MODEL OF HIGH-SHEAR INDUCED STENT THROMBOSIS
Autore:
MAKKAR RR; EIGLER NL; KAUL S; FRIMERMAN A; NAKAMURA M; SHAH PK; FORRESTER JS; HERBERT JM; LITVACK F;
Indirizzi:
CEDARS SINAI MED CTR,BURNS & ALLENS RES INST,DEPT MED,DIV CARDIOL,CARDIOVASC INTERVENT RES CTR LOS ANGELES CA 90048 UNIV CALIF LOS ANGELES,SCH MED LOS ANGELES CA 00000 SANOFI RECH F-31036 TOULOUSE FRANCE
Titolo Testata:
European heart journal
fascicolo: 10, volume: 19, anno: 1998,
pagine: 1538 - 1546
SICI:
0195-668X(1998)19:10<1538:EOCAAC>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANSLUMINAL CORONARY ANGIOPLASTY; CYCLIC FLOW VARIATIONS; PALMAZ-SCHATZ STENTS; BALLOON ANGIOPLASTY; ARTERIOVENOUS SHUNT; THREATENED CLOSURE; ARTERY DISEASE; ADP; IMPLANTATION; PLATELETS;
Keywords:
STENT; PLATELETS; ANGIOPLASTY; STENT THROMBOSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
39
Recensione:
Indirizzi per estratti:
Citazione:
R.R. Makkar et al., "EFFECTS OF CLOPIDOGREL, ASPIRIN AND COMBINED THERAPY IN A PORCINE EX-VIVO MODEL OF HIGH-SHEAR INDUCED STENT THROMBOSIS", European heart journal, 19(10), 1998, pp. 1538-1546

Abstract

Aims Use of ticlopidine in coronary stenting is limited by delayed onset of action. We studied the effects of clopidogrel, a rapidly actinganalog of ticlopidine alone, and in combination with aspirin, in inhibiting stent thrombosis. Methods Unpolished nitinol stents were deployed in a porcine ex vivo arteriovenous shunt and exposed to flowing arterial blood at a shear rate of approximately 1500.s(-1). Stent thrombus. platelet aggregation and bleeding times were measured at baseline and after treatment. Results Intravenous clopidogrel produced a rapid (within 30 min) and dose-dependent inhibition of stent thrombosis, with87% reduction at a dose of 10 mg. kg(-1) (P<0.001). Aspirin alone (10mg.kg(-1)) was minimally effective (20% inhibition P>0.05) in inhibiting stent thrombosis. Combined treatment with clopidogrel and aspirin produced 95-98% inhibition of stent thrombosis, even at low doses of clopidogrel (2.5-5.0 mg.kg(-1)) (P<0.0001). At effective doses both clopidogrel and combined therapy produced significant prolongation of bleeding time (P<0.05) and inhibition of platelet aggregation (P<0.05). Conclusion Clopidogrel, either alone or combined with aspirin, may havea potential role in preventing stent thrombosis in high-risk clinicalsituations.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 18:34:44