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Titolo:
REGULATION OF GLUCOSE-TRANSPORT IN CULTURED SCHWANN-CELLS
Autore:
MAGNANI P; THOMAS TP; TENNEKOON G; DEVRIES GH; GREENE DA; BROSIUS FC;
Indirizzi:
EDWARD HINES JR VET ADM HOSP,RES 151,5TH AVE & ROOSEVELT RD HINES IL 60141 EDWARD HINES JR VET ADM HOSP HINES IL 60141 UNIV MICHIGAN,MED CTR,DEPT PEDIAT & COMMUNICABLE DIS ANN ARBOR MI 48109 UNIV MICHIGAN,MED CTR,DEPT INTERNAL MED ANN ARBOR MI 48109 UNIV MICHIGAN,MED CTR,MICHIGAN DIABET RES & TRAINING CTR ANN ARBOR MI48109 LOYOLA UNIV,STRITCH SCH MED,DEPT CELL BIOL NEUROBIOL & ANAT MAYWOOD IL 60153
Titolo Testata:
Journal of the peripheral nervous system
fascicolo: 1, volume: 3, anno: 1998,
pagine: 28 - 36
SICI:
1085-9489(1998)3:1<28:ROGICS>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
AXOLEMMA-ENRICHED FRACTIONS; RAT PERIPHERAL-NERVE; ALDOSE REDUCTASE; SCIATIC-NERVE; UNMYELINATED NERVES; PERINEURIAL CELLS; AXONAL SIGNALS; TISSUE-CULTURE; EXPRESSION; MYELIN;
Keywords:
GLUCOSE TRANSPORT; PERIPHERAL NERVE; SCHWANN CELLS; DIABETES MELLITUS; RAT; NEUROPATHY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
51
Recensione:
Indirizzi per estratti:
Citazione:
P. Magnani et al., "REGULATION OF GLUCOSE-TRANSPORT IN CULTURED SCHWANN-CELLS", Journal of the peripheral nervous system, 3(1), 1998, pp. 28-36

Abstract

Glucose is the major source of metabolic energy in the peripheral nerve. Energy derived from glucose is mostly utilized for axonal repolarization. One route by which glucose may reach the axon is by crossing the Schwann cells that initially surround the axons. Considering the ability of neurons to control many glial cell functions, we postulated that Schwann cell glucose transporters might be transiently regulated by axonal contact. Glucose transport was studied in a cultured, differentiated rat Schwann cell line stably expressing SV40 T antigen regulated by a synthetic mouse metallothionein promoter. (3)[H]-2-deoxy-D-glucose uptake was measured in cultured cells in basal and in various experimental conditions. Glucose transporter gene expression was determined after RNA isolation from cultured cells through Northern and RNAse protection assay. In vitro, Schwann cells were found to express high-affinity, insulin-insensitive, facilitative glucose transporters and predominantly GLUT1 mRNA. Schwann cell 2-deoxyglucose uptake was increased by axolemmal membranes or forskolin but unchanged by elevated glucose levels. Regulation of Schwann cell glucose transporters by axolemmaand their resistance to glucose-induced down-regulation suggest extrinsic rather than intrinsic regulation that might enhance Schwann cell vulnerability to glucotoxicity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 01:41:03