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Titolo:
EXPRESSION OF KV1.5K-VIVO( CHANNELS IN ACTIVATED MICROGLIA IN)
Autore:
JOU I; PYO H; CHUNG SK; JUNG SY; GWAG BJ; JOE EH;
Indirizzi:
SAN 5 WONCHEON DONG PALDAL GU SUWON 442749 KYUNGGI DO SOUTH KOREA AJOU UNIV,SCH MED,DEPT PHARMACOL SUWON 441749 SOUTH KOREA CHUNG ANG UNIV,COLL MED,DEPT PHYSIOL SEOUL 156756 SOUTH KOREA
Titolo Testata:
Glia (New York, N.Y. : Print)
fascicolo: 4, volume: 24, anno: 1998,
pagine: 408 - 414
SICI:
0894-1491(1998)24:4<408:EOKCIA>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
GATED K+ CHANNELS; POTASSIUM CHANNEL; RAT MICROGLIA; PERITONEAL-MACROPHAGES; CELL-PROLIFERATION; INTERFERON-GAMMA; LIPOPOLYSACCHARIDE; INDUCTION; CALCIUM; DEPOLARIZATION;
Keywords:
MICROGLIA; K+ CHANNELS; ACTIVATION; LPS; INOS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
45
Recensione:
Indirizzi per estratti:
Citazione:
I. Jou et al., "EXPRESSION OF KV1.5K-VIVO( CHANNELS IN ACTIVATED MICROGLIA IN)", Glia (New York, N.Y. : Print), 24(4), 1998, pp. 408-414

Abstract

We examined the expression of outward rectifier K+ channels in activated microglia in vivo. For this purpose, lipopolysaccharide (LPS, 2 mug) was injected into the cortex near the hippocampal region of rat brains, and K+ channel expression was examined using antibodies against shaker-type K+ channels, Kv1.5 and Kv1.3. OX-42-positive microglia were found around the injection sites from 8 h after the LPS injection and remained there for 3 days. The OX-42-positive microglia expressed Kv1.5 immunoreactivity, and the time course of Kv1.5 expression was closely correlated with that of OX-42. In saline-injected brains, OX-42-positive cells also expressed Kv1.5 immunoreac tivity even though far fewer OX-42-positive cells were found. Increase of Kv1.5 expression after LPS injection was also demonstrated by immunoblot analysis. On the other hand, Kv1.3 immunoreactivity was barely detected in OX-42-positive cells over the entire experimental period. The expression of Kv1.5 preceded that of inducible nitric oxide synthase (iNOS), which is a prominent indication of microglial activation. iNOS was not detectable until 12 h, and thereafter it was maintained for 3 days together with Kv1.5 and OX-42. These results suggest that in vivo as well as in vitro activated microglia expressed outward K+ channels and that some of thechannels at least are Kv1.5. GLIA 24:408-414, 1998. (C) 1998 Wiley-Liss, Inc.

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Documento generato il 01/10/20 alle ore 01:28:32