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Titolo:
THE INFLUENCE OF PARENTERAL GLUTAMINE AND BRANCHED-CHAIN AMINO-ACIDS ON TOTAL PARENTERAL-NUTRITION INDUCED ATROPHY OF THE GUT
Autore:
PLATELL C; MCCAULEY R; MCCULLOCH R; HALL J;
Indirizzi:
UNIV PERTH,ROYAL PERTH HOSP,DEPT SURG,WELLINGTON ST PERTH WA 6000 AUSTRALIA UNIV PERTH,ROYAL PERTH HOSP,DEPT SURG,WELLINGTON ST PERTH WA 6000 AUSTRALIA
Titolo Testata:
JPEN. Journal of parenteral and enteral nutrition
fascicolo: 4, volume: 17, anno: 1993,
pagine: 348 - 354
SICI:
0148-6071(1993)17:4<348:TIOPGA>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
ORNITHINE-ALPHA-KETOGLUTARATE; PROTEIN SYNTHETIC RATE; NITROGEN-BALANCE; SKELETAL-MUSCLE; SUBSTRATE FLUX; INFUSIONS; FOREARM; SURGERY; COLON;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
C. Platell et al., "THE INFLUENCE OF PARENTERAL GLUTAMINE AND BRANCHED-CHAIN AMINO-ACIDS ON TOTAL PARENTERAL-NUTRITION INDUCED ATROPHY OF THE GUT", JPEN. Journal of parenteral and enteral nutrition, 17(4), 1993, pp. 348-354

Abstract

We tested the hypothesis that the provision of glutamine and branched-chain amino acids would reverse the gut atrophy that accompanies parenteral nutrition. Three hundred seventy-five rats were randomized into15 groups to receive either conventional parenteral nutrition, rat food, glutamine-enriched parenteral nutrition (0.5% to 2.5%), branched-chain amino acid-enriched parenteral nutrition (0.8% to 2.0%), or glutamine plus branched-chain amino acid-enriched parenteral nutrition (0.5%/0.4% to 1.25%/1/0%). When compared with effects of conventional parenteral nutrition, the infusion of either glutamine or branched-chain amino acids partially reversed, in a dose-dependent manner, atrophy of the small bowel as assessed by gut weight (p < .05), mucosal weight (p< .05), villous height (p < .05), crypt cell production rate (p < .05), and mucosal protein concentration (p < .05). There was no effect onthe large bowel. These results suggest that the parenteral infusion of either glutamine or branched-chain amino acids partially reverses the small-bowel atrophy that is associated with the infusion of solutions of conventional parenteral nutrients.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 07:40:02