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Titolo:
HIV GP120 AND PMA/IONOMYCIN INDUCED APOPTOSIS BUT NOT ACTIVATION-INDUCED CELL-DEATH REQUIRE PKC FOR FAS-L UP-REGULATION/
Autore:
ACCORNERO P; RADRIZZANI M; CARE A; MATTIA G; CHIODONI C; KURRLE R; COLOMBO MP;
Indirizzi:
IST NAZL TUMORI,DIV EXPT ONCOL D,VIA VENEZIAN 1 I-20133 MILAN ITALY IST NAZL TUMORI,DIV EXPT ONCOL D I-20133 MILAN ITALY IST SUPER SANITA I-00161 ROME ITALY BEHRINGWERKE AG D-3550 MARBURG GERMANY
Titolo Testata:
FEBS letters
fascicolo: 3, volume: 436, anno: 1998,
pagine: 461 - 465
SICI:
0014-5793(1998)436:3<461:HGAPIA>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-IMMUNODEFICIENCY-VIRUS; CD4(+) T-CELLS; PROTEIN-KINASE-C; LIGAND EXPRESSION; CROSS-LINKING; LYMPHOCYTE CLONES; HIV-INFECTION; TH1 CLONE; CD95; MECHANISM;
Keywords:
HUMAN IMMUNODEFICIENCY VIRUS; GP120; APOPTOSIS; PROTEIN KINASE C; FAS; CD4(+) TH1 CLONE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
41
Recensione:
Indirizzi per estratti:
Citazione:
P. Accornero et al., "HIV GP120 AND PMA/IONOMYCIN INDUCED APOPTOSIS BUT NOT ACTIVATION-INDUCED CELL-DEATH REQUIRE PKC FOR FAS-L UP-REGULATION/", FEBS letters, 436(3), 1998, pp. 461-465

Abstract

HIV protein gp120 in combination with T cell antigen receptor (TCR) triggering induces apoptosis (gp120-apoptosis) in Th1 cells. Gp120-apoptosis occurs by induction of Fas-L and subsequent triggering of the Fas apoptotic pathway. Here, through the use of several compounds inhibiting induction of Fast, we show that, in a Th1 clone, a protein kinaseC (PKC) independent pathway activated by TCR stimulation is distinguishible from a PKC dependent pathway activated by either phorbol 12-myristate 13-acetate (PMA)/ionomycin or asynchronous stimulation of TCR and CD4 as occurs in gp120-apoptosis, (C) 1998 Federation of European Biochemical Societies.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/10/20 alle ore 07:44:37