Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
LY354740, A GROUP-II METABOTROPIC GLUTAMATE-RECEPTOR AGONIST WITH POTENTIAL ANTIPARKINSONIAN PROPERTIES IN RATS
Autore:
KONIECZNY J; OSSOWSKA K; WOLFARTH S; PILC A;
Indirizzi:
POLISH ACAD SCI,INST PHARMACOL,DEPT NEUROPSYCHOPHARMACOL,12 SMETNA STPL-31343 KRAKOW POLAND POLISH ACAD SCI,INST PHARMACOL,DEPT NEUROBIOL PL-31343 KRAKOW POLAND
Titolo Testata:
Naunyn-Schmiedeberg's archives of pharmacology
fascicolo: 4, volume: 358, anno: 1998,
pagine: 500 - 502
SICI:
0028-1298(1998)358:4<500:LAGMGA>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXCITATORY AMINO-ACIDS; PARKINSONS-DISEASE;
Keywords:
GROUP II METABOTROPIC RECEPTORS; PARKINSONISM; MUSCLE RIGIDITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
10
Recensione:
Indirizzi per estratti:
Citazione:
J. Konieczny et al., "LY354740, A GROUP-II METABOTROPIC GLUTAMATE-RECEPTOR AGONIST WITH POTENTIAL ANTIPARKINSONIAN PROPERTIES IN RATS", Naunyn-Schmiedeberg's archives of pharmacology, 358(4), 1998, pp. 500-502

Abstract

The aim of this study was to examine whether (+)-2-aminobicyclo[3.1.0]-hexane-2,6-dicarboxylate monohydrate (LY354740), a selective agonistof group II metabotropic glutamate receptors, possesses antiparkinsonian properties. Parkinsonian-like muscle rigidity was induced by pretreatment with haloperidol (1 mg/kg i.p.). It was measured as increased resistance developed by the rat's hind leg to passive extension and flexion. LY354740 (5 and 10 mg/kg i.p.) dose-dependently diminished the haloperidol-induced muscle rigidity. The present results suggest that LY354740 counteracts the muscle rigidity in an animal model of parkinsonism.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 18:37:47